Synthesis of Phenylacetic Acid - Erowid
Phenylacetic acid. 2.4g (16 mmol) methyl phenylacetate and 10ml 2M NaOH is refluxed for 2h. The free phenylacetic acid is precipitated by the addition of conc HCl (~3ml), in 92% yield, mp 76-76.5°C. The Willgerodt Reaction can also be used to transform acetophenone (or styrene) to phenylacetic acid. Phenylacetic Acid From Ethylbenzene [6,7]
Phenylacetic acid - Wikipedia
Phenylacetic acid (conjugate base phenylacetate), also known by various synonyms, is an organic compound containing a phenyl functional group and a carboxylic acid functional group. It is a white solid with a strong honey-like odor. Endogenously, it is a catabolite of phenylalanine.
Phenylacetic Acid Properties, Reactions and Applications
Phenylacetic acid can be obtained by hydrolysis of phenylacetonitrile, which is the most common route of synthesis. Sulfuric acid is often used as a catalyst, usually at a concentration of 70%, but concentrated hydrochloric acid can also be used.
Phenylacetic Acid - an overview | ScienceDirect Topics
Synthesis and use of α-methoxy-α-(trifluoromethyl) phenylacetic acid (MTPA) 4, a chiral reagent for determination of enantiomeric purity of alcohols and amines by NMR.
Phenylacetic Acid | C8H8O2 | CID 999 - PubChem
A catalytic process for the synthesis of phenylacetic acid from benzyl chloride uses Ni(CO)4 as catalyst. The product is formed with a selectivity of 95% at 60 bar and 80 °C.
An improved method for the synthesis of phenylacetic acid …
2019年10月8日 · 2,4-Dichlorophenylacetic acid is synthesized in high yield via the carbonylation of 2,4-dichlorobenzyl chloride, and various experimental conditions are evaluated.
Synthesis of phenylacetic acid by carbonylation - ScienceDirect
2000年9月22日 · In the present communication, we report the successful direct carbonylation of benzyl alcohol to phenylacetic acid catalyzed by rhodium complexes. The process uses benzyl alcohol and carbon monoxide (CO) as the starting materials, benzyl chloride and KI as promoters, and a hydrated rhodium chloride as the catalyst precursor. 2. Experimental. 2.1.
Organic Syntheses Procedure
The standard method for the preparation of phenylacetic acid is the hydrolysis of benzyl cyanide with either alkali 1 or acid. 2 The acid hydrolysis runs by far the more smoothly and so was the only one studied.
Metabolic engineering of Escherichia coli to high efficient synthesis ...
2017年5月25日 · We establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine in E. coli with heterologous coexpression of aminotransferase (ARO8), keto acid decarboxylase (KDC) and aldehyde dehydrogenase H (AldH) gene.
Iodide-catalyzed reductions: development of a synthesis of phenylacetic …
2011年11月18日 · A new convenient and scalable synthesis of phenylacetic acids has been developed via the iodide catalyzed reduction of mandelic acids. The procedure relies on in situ generation of hydroiodic acid from catalytic sodium iodide, employing phosphorus acid as the stoichiometric reductant.