PHENACETIN - Pharmaceuticals - NCBI Bookshelf
Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease …
Phenacetin - Wikipedia
Phenacetin ⓘ (acetophenetidin, N- (4-ethoxyphenyl)acetamide[1]) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973, [2] and by the U.S. Food and Drug Administration in 1983 [3]).
Phenacetin: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Phenacetin was the first NSAID and fever reducer to go on the market. It acts as an analgesic at the spinal cord as well as a negative inotrope at the heart. It can be used to treat subacute rheumatoid arthritis, intercostal neuralgia, and …
Phenacetin - an overview | ScienceDirect Topics
Phenacetin, a painkiller, was the world’s first synthetic pharmaceutical drug. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities. Phenacetin was developed in 1878 by an American chemist, Harmon Northrop Morse.
Phenacetin and Analgesic Mixtures Containing Phenacetin
2021年12月21日 · Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. It was introduced into therapy in 1887 and was extensively used in analgesic mixtures until it was implicated in kidney disease (nephropathy) due to abuse of analgesics ( Flower et al. 1985 ) and was withdrawn from the U.S. market ...
NCATS Inxight Drugs — PHENACETIN
Phenacetin was used as an analgesic and fever-reducing drug in both human and veterinary medicine for many years. Since a major portion of a dose of phenacetin is rapidly metabolised to paracetamol, it seems possible that phenacetin owes some of its therapeutic activity to its main metabolite, paracetamol, whereas its most troublesome side ...
Phenacetin | C10H13NO2 | CID 4754 - PubChem
Phenacetin is a member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group. It has a role as a non-narcotic analgesic, a peripheral nervous system drug and a cyclooxygenase 3 inhibitor. It is a member of acetamides and an aromatic ether.
Paracetamol and Phenacetin | Drugs - Springer
2012年10月17日 · Both paracetamol and phenacetin are effective mild analgesics, suitable for treating mild to moderate pain, and their actions are broadly comparable with those of aspirin and related salicylates, although they do not appear to possess significant anti-inflammatory activity.
PHENACETIN (Group 2A) and ANALGESIC MIXTURES CONTAINING PHENACETIN …
Phenacetin given orally induced benign and malignant tumours of the urinary tract in mice 20 and rats 1, 21 and of the nasal cavity in rats 1. When given in combination with aspirin and caffeine to rats or mice, no significant association was found with the incidence of tumours 1.
Phenacetin - an overview | ScienceDirect Topics
Phenacetin, a painkiller, was the world's first synthetic pharmaceutical drug. It was one of the first painkillers that was not derived from opium while at the same time being absent of anti-inflammatory qualities. Phenacetin was developed in 1878 by an American chemist, Harmon Northrop Morse.
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