Peptoids (root from the Greek πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest" and the Greek-derived suffix -oid meaning "like, like that of, thing like a ______," ), or poly- N -substituted glycines, are a class of biochemicals known as biomimetics that replicate the behavior of biological molecules. [1] .

The Peptoid Data Bank allows researchers to search for peptoids published by specific authors, containing specific residues, with a certain DOI, topology, or ones solved by one of the two experimental techniques.

类肽 （英語： Peptoid）或 聚-N-取代甘氨酸 （英語： Poly-N-substituted glycine）是一类 拟肽 化合物，相当于将 肽 中的主链α碳侧链转移为主链氮取代侧链。 在类肽中，肽中主链上的氨基酸α碳取代侧链被转移至主链氮上。 值得一提的是，由于缺少了主链氮上的氢，类肽一般不能够形成类似于肽和蛋白中的 二级结构 一样的高级有序结构。 类肽由 Reyna J. Simon, Paul Bartlett 和 Daniel V. Santi 发明，最初目的是开发对蛋白酶稳定的拟肽小分子药物。 [1][2]

Peptoids are peptidomimetics that contain N -substituted glycines, which provide improved proteolytic stability due to the absence of amide bonds in their backbone. Peptoids have structural motifs similar to those of peptides and can be readily …

2008年2月26日 · Antimicrobial peptides (AMPs) and their mimics are emerging as promising antibiotic agents. We present a library of “ampetoids” (antimicrobial peptoid oligomers) with helical structures and biomimetic sequences, several members of which have low-micromolar antimicrobial activities, similar to cationic AMPs like pexiganan.

2019年6月11日 · Maxwell Biosciences is developing a new class of potent, safe, biostable synthetic peptide-like small molecules currently in toxicology testing to treat common viral infections in humans. Read more about how peptoids mimic natural virucides.

Peptoids have emerged as a valuable class of foldamers for the study of biomolecular interactions and hold promise as therapeutic agents. This perspective analyzes the importance of peptoid structure in the discovery of biologically active peptoids over the past five years.

Peptoids (N-substituted glycine oligomers) are a relatively new class of peptidomimetics, being highly versatile and capable of mimicking the architectures and the activities of the peptides but with a marked resistance to proteases and a propensity to cross the cellular membranes over the peptides themselves.

Peptoids, oligomers of N-substituted glycines, are described as a motif for the generation of chemically diverse libraries of novel molecules. Ramachandran-type plots were calculated and indicate a greater diversity of conformational states available for peptoids than for peptides.

2013年5月30日 · Polypeptoids, a promising class of bioinspired polymer based on a N-substituted glycine backbone, have a number of unique properties that bridge the material gap between proteins and bulk polymers.