The Penicillin Allergy Decision Rule (PEN-FAST) identifies low-risk penicillin allergies.

The PEN-FAST penicillin allergy clinical decision rule enables point-of-care risk assessment of patient-reported penicillin allergies. It requires three clinical criteria: Time (five years or less) from penicillin allergy episode (2 points)

PEN-FAST is a clinical decision-making tool with a high negative predictive value (NPV) that can identify patients with low-risk penicillin allergy who do not require skin testing prior to oral penicillin challenge. 1 We aimed to validate PEN-FAST in risk stratification of reported penicillin allergies at a large tertiary health care system ...

2023年7月19日 · PEN-FAST is a clinical decision-making tool that effectively identifies patients with self-reported penicillin allergy who are at negligible risk of hypersensitivity reaction after exposure to these antibiotics.

2020年5月1日 · The results suggest that a PEN-FAST score of less than 3, associated with a high negative predictive value, could be used by clinicians and antimicrobial stewardship programs to identify low-risk penicillin allergies at the point of care.

Results: The four features associated with a penicillin allergy positive test on multivariate analysis were summarized in the mnemonic “PEN-FAST” (Penicillin allergy, within last five years, anaphylaxis/angioedema, severe cutaneous adverse reaction (SCAR) and treatment required for allergy episode).

PEN-FAST is a point-of-care tool to identify low-risk penicillin allergy patients. We aimed to validate PEN-FAST in a large multi-site US-based registry that records patient-reported allergy history.

2022年3月1日 · Penicillin skin testing is recommended for patients at moderate or high risk (PEN-FAST score ≥ 3) or with unknown history, current pregnancy, or hemodynamic instability. The skin test is the most reliable way to demonstrate penicillin-specific IgE antibodies.

PEN-FAST can be used for adult patients (age ≥ 18) with a documented penicillin allergy who need syphilis treatment. It is not appropriate for pregnant patients. *Pregnant patients may require desensitization; consult with allergy or infectious disease.

Inaccurate penicillin allergy labeling may deter healthcare providers from initiating appropriate therapy and contribute to antibiotic resistance. In a rural urgent care setting, the current practice of penicillin allergy labeling was evaluated using the PEN-FAST tool.