Pegaspargase (Oncaspar ®), a pegylated form of native Escherichia coli -derived l -asparaginase (hereafter referred as E. colil -asparaginase), is indicated in the USA and EU for the treatment …

MECHANISM OF ACTION: Pegaspargase is a pegylated conjugate of L-asparaginase (E. coli-derived asparaginase, asparaginase E. coli). It is comprised of a polyethylene glycol (PEG) …

Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6][7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and …

The use of asparaginase in acute lymphoblastic leukemia. Currently, three different types of ASP are available for use in the treatment of ALL. Native E. coli ASP and pegylated (PEG)-ASP are …

2005年6月13日 · Mechanism of action. Pegaspargase is a pegylated L-asparaginase that catalyzes the conversion of the amino acid L-asparagine into aspartic acid and ammonia. …

Toxicities due to asparaginase (right panel) occur through a variety of mechanisms including decreased protein synthesis, direct effects on metabolites, or more complex mechanisms. …

PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene glycol, was rationally synthesized to decrease immunogenicity of the enzyme and prolong its …

The first trial, 91-01, randomized patients to receive E. coli (25,000 IU/m 2 /wk) versus PEG (2,500 U/m 2 /every other week) asparaginase during 30 weeks of intensification therapy and …

Mechanism of Action. L-asparaginase is an enzyme that catalyzes conversion of amino acid L-asparagine into aspartic acid and ammonia. Mechanism of action believed to be based on the …

2008年6月26日 · We investigated the clinical response in vivo of 1000 IU/m 2 pegylated (PEG)-asparaginase and its pharmacokinetic, pharmacodynamic and intracellular effects in children …