Proliferating cell nuclear antigen - Wikipedia
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin ...
增殖细胞核抗原 - 百度百科
增殖细胞核抗原（Proliferating Cell Nuclear Antigen简称PCNA）由Miyachi等于1978年在 SLE（系统性红斑狼疮）患者的血清中首次发现并命名，因其只存在于正常增殖细胞及肿瘤细胞内而得名，以后的研究发现PCNA与细胞DNA合成关系密切，在细胞增殖的启动上起重要作用，是 ...
Comparison of the value of PCNA and Ki-67 as markers of cell ...
Proliferating Cell Nuclear Antigen (PCNA) is a nuclear nonhistone protein that is necessary for DNA synthesis and is an accessory protein for DNA polymerase alpha, which is elevated during the G1/S phase of the cell cycle. Quiescent and senescent cells have very low levels of …
Proliferating cell nuclear antigen (PCNA): a new marker to study …
Immunohistochemistry of the S phase related proliferating cell nuclear antigen (PCNA) was studied as an alternative to ex-vivo bromodeoxyuridine (BrdU) immunohistochemistry for assessment of human colonic cell proliferation.
PCNA Staining of Retinal Cryosections to Assess Microglial
Detection of the protein PCNA (proliferating cell nuclear antigen) is used to identify cells in the S phase of the cell cycle to indicate cellular proliferation. Here we describe our method to detect PCNA expression by microglia and macrophages in retinal cryosections.
Proliferating cell nuclear antigen (PCNA): a key factor in DNA ...
PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast, plant and animal cells that undergo cell division, suggesting a function in cell cycle regulation and/or DNA replication. It subsequently became clear that PCNA also played a role in other processes involving the cell genome.
Discrimination of cell cycle phases in PCNA-immunolabeled cells
2015年5月29日 · Proliferating cell nuclear antigen (PCNA) is a protein which is involved in DNA replication and has cell cycle dependent properties. In this work, we present a tool to identify cell cycle phases and in particular, sub-stages of the DNA replication phase (S-phase) based on the characteristic patterns of PCNA distribution.
Assessment of proliferating cell nuclear antigen (PCNA) …
2019年10月31日 · Proliferating cell nuclear antigen (PCNA) is a nuclear marker known to reflect cell turnover and may be used as a marker for tumour aggressiveness. Twenty cases of OSCC were histologically assessed to evaluate the correlation between proliferating cell nuclear antigen expression and invasive front grading.
Immunohistochemical staining of proliferating cell nuclear antigen ...
Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) was performed in skin from patients with various malignant and nonmalignant skin diseases using anti-PCNA monoclonal antibodies. The malignant diseases included squamous cell carcinoma (SCC), adult T lymphotrophic leukemia (AT …
Analysis of Proliferating Cell Nuclear Antigen (PCNA ... - Springer
Proliferating cell nuclear antigen (PCNA) is a homotrimeric protein adopting a ring structure that may encircle DNA. In this form, PCNA functions as a sliding platform to which different types of catalytic and regulatory proteins are tethered to perform DNA...
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