PB28 is a cyclohexylpiperazine derivative and a high affinity and selective sigma 2 (σ2) receptor agonist with a K i of 0.68 nM. PB28 is also a σ1 antagonist with a K i of 0.38 nM. PB28 is less …

2020年12月7日 · Sigma-1 and sigma-2 receptors surprisingly belong to the "druggable" host proteins found, with the pan-sigma receptor modulator PB28 displaying the most potent anti …

2021年11月16日 · PB28 significantly inhibited the proliferative and invasive ability of OS-RC-2 cells in vivo. Treatment resulted in decreased phosphorylation of constituents of the PI3K-AKT …

2020年12月6日 · PB28 is a subnanomolar affinity sigma-1 and sigma-2 receptors ligand that was produced in our laboratory in the 1990s (Berardi et al., 1996; Berardi et al., 2004; Berardi et …

2020年12月8日 · PB28 is a sigma-1 antagonist and a sigma-2 agonist (Table 3). These findings proposed PB28 as a potential antitumor agent prompting its investigation in several tumor cell …

2008年3月15日 · The results showed that [3 H]PB28 and the corresponding unlabelled PB28 had superimposed pharmacodynamic properties. This radioligand appears as a potential candidate …

PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a K i of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with …

PB28: 一种σ2 receptor激动剂药物，由University of Bari (University of Bari)公司最早进行研发，目前全球最高研发状态为临床前，作用机制: σ2 receptor激动剂(Sigma-2受体激动剂)，治疗领 …

2020年10月10日 · PB28, a cyclohexylpiperazine derivative, could be a potential strategy for Covid 19 because in a recent study it has been found more active than hydroxychloroquine without …