Podocyte-Associated Molecules in Puromycin Aminonucleoside
2002年6月1日 · To study the molecular mechanisms involved in the impairment of the glomerular ultrafiltration barrier manifesting as proteinuria, the well-established puromycin aminonucleoside nephrosis (PAN)...
A kidney-specific fasting-mimicking diet induces podocyte ... - AAAS
2024年10月30日 · We generated spatial maps of gene expression of kidney sections from a healthy rat (control), a PAN-treated rat (PAN), and an age-matched PAN-treated rat after six cycles of LS-FMD (PAN/LS-FMD). Kidney structures with representative gene expression are shown in fig. S9A; we used established renal markers to match transcriptionally defined ...
肾小球肾炎和钠潴留：嘌呤霉素诱导的肾病综合征大鼠和自发性狼 …
背景 在嘌呤霉素氨基葡萄糖苷诱导 (PAN) 肾病综合征大鼠中，显微穿刺研究已将钠潴留部位定位到集合管。我们已经证实了这一发现，证明 Na+/K+-ATPase 活性增加了两倍，特别限于 PAN 大鼠的皮质集合管。
TRPC5 Channel Inhibition Protects Podocytes in Puromycin ...
2021年9月20日 · A single dose of PAN treatment successfully increased TRPC5 single-channel activity in response to the TRPC5 agonist riluzole, while systemic co-administration of AC1903 with PAN in rats significantly reduced TRPC5 activity from isolated glomeruli .
Disorder of fatty acid metabolism in the kidney of PAN-induced ...
To induce nephrotic syndrome, Sprague-Dawley rats (SDRs) and Nagase analbuminemic rats (NARs) with inherited hypoalbuminemia were treated with a single injection of puromycin aminonucleoside (PAN). In SDRs, PAN treatment induced massive proteinuria and albuminuria and caused tubular damage, apoptosis, and lipid accumulation in PTECs.
Experimentally induced puromycine aminonucleoside nephrosis (PAN…
2012年2月16日 · In this study, we aimed to examine PD-ECGF expression in acute and chronic PAN induced in rats and find out the association between its expression and the stages of angiogenesis in kidney.
TRPC5 Channel Inhibition Protects Podocytes in Puromycin ...
2021年9月21日 · To investigate the role of TRPC5 in PAN nephrosis, we administered a single dose of PAN (50 mg/kg body weight rats), which induced a significant amount of urine albumin 7 days after injection. In contrast, co-administration of the TRPC5 channel inhibitor AC1903 twice per day significantly reduced urine albumin 7 days after PAN injection ...
Experimentally induced puromycine aminonucleoside nephrosis (PAN…
2012年2月16日 · In this study, we aimed to examine PD-ECGF expression in acute and chronic PAN induced in rats and find out the association between its expression and the stages of angiogenesis in kidney. For the experiment, twenty-four Male Wistar Albino rats were used and divided into four groups; control group (n = 6), pre-proteinuria group (n = 6), acute ...
Podocyte-secreted angiopoietin-like-4 mediates proteinuria in ...
2010年12月12日 · As part of our studies to identify mechanisms of proteinuria, we injected rats with the γ2 fraction of nephrotoxic serum (γ2-NTS), an antiserum that is reactive to many podocyte proteins and...
Regulation of the Proximal Tubular Sodium/Proton Exchanger N ...
PAN rats developed reduced GFR, severe proteinuria, and sodium retention within 3 d. After 10 d, immunoblots of brush border vesicles revealed a decreased abundance of NHE3 in nephrotic animals. However, the Na/H antiporter activity in the same vesicle preparations was not significantly altered.