2024年8月10日 · We demonstrate that PAK4 promotes insulin resistance by phosphorylating AMPKα2 at Ser491, thereby inhibiting AMPK activity. We additionally show that skeletal muscle-specific expression of a...

2017年5月22日 · We identified grade-dependent p21-activated kinases 4 (PAK4) upregulation in gliomas and further determined its role in mesenchymal transition and radioresistance. IR treatment significantly...

2022年10月1日 · In this paper, we systematically review the role of PAK4 in cancer, including its structure, localization, expression, upstream regulators and essential functions in cancer. We also discuss recently reported PAK4 inhibitors based on their structure types.

2023年1月1日 · PAK4 acts as a serine/threonine kinase in response to Rho GTPases, while interaction partners and substrates are rapidly extended, implying a diverse range of cellular functions regulated by PAK4, including cell cycle progression, proliferation, survival, cell adhesion, motility, neuronal development, and immune defense.

2015年11月9日 · PAK4 overexpression increased EMT in glioma cells by elevating N-cadherin and vimentin levels. Conversely, specific shRNA-mediated PAK4 downregulation led to loss of mesenchymal phenotype in these cells. Further, irradiation (IR, 8 Gy) treatment significantly increased PAK4 nuclear localization in correlation with increased EMT in IR-treated cells.

2017年9月14日 · We identified grade-dependent p21-activated kinases 4 (PAK4) upregulation in gliomas and further determined its role in mesenchymal transition and radioresistance. IR treatment significantly elevated expression and nuclear localization of PAK4 in correlation with induction of reactive oxygen species (ROS) and mesenchymal transition in GBM cells.

2021年9月1日 · Together with Cdc42V12 expression, PAK4 participates in filopodia formation. PAK4 also regulates IRF and TNF-α expression levels which are involved in the immune response. PAK4 confers cancer cells resistance to treatments via activation of PI3K/AKT and Wnt/β-catenin signaling pathways which are also involved in cell survival and proliferation.

PAK4 是 P21 活化蛋白激酶（p21-activated protein kinase, PAK）家族中的一员，通过对下游底物的磷酸化来参与并调节细胞增殖、分化、细胞骨架重构以及细胞凋亡等众多细胞重要过程。

摘要： 丝氨酸/苏氨酸蛋白激酶4 (p21-activated kinases 4, PAK4)，是生物学界新发现的一种蛋白因子，在细胞信号转导过程中起重要作用。 研究发现PAK4与细胞凋亡、肿瘤发生、细胞骨架重建等关系密切。 本文对PAK4与细胞骨架重组、抑制细胞凋亡及肿瘤形成转移等生物学特性作一综述。 中图分类号: 胡元庆 (综述), 张宏权 (审校). 丝氨酸/苏氨酸蛋白激酶4生物学特性的研究进展 [J]. 癌变·畸变·突变, 2010, 22 (1): 75-0077. 导出引用管理器 EndNote | Reference Manager | …

2020年12月3日 · p21 活化激酶4 (p21-activated kinase 4，PAK4) 是丝氨酸/苏氨酸蛋白激酶，参与体内多条信号通路，影响肿瘤细胞的增殖、存活、侵袭转移及凋亡，对肿瘤的发生发展起着重要作用。 PAK4被研究、关注已经有20多年的历史，期间不断有新的PAK4抑制剂被开发出来，仅2020年报导的PAK4抑制剂文章就已多达近十篇，然而针对PAK4靶点的产品进入临床者寥寥，上市的更是没有。 目前，曾进入临床的PAK4抑制剂有辉瑞PF-3758309和Karyopharm …