Results have shown that the activity of DA neurons in DRN changes in response to pain, and these changes can mediate pain-related hyperalgesia by affecting dopamine synthesis and downstream neuronal circuits.

2024年9月28日 · The dorsal raphe nucleus (DRN) has gained attention owing to its involvement in various physiological functions, such as sleep-awake, feeding, and emotion, with its analgesic role being particularly significant. It is described as the "pain inhibitory nucleus" in the brain. The DRN has diverse proje …

2023年8月23日 · The DRN is composed of molecularly and functionally heterogeneous neural subpopulations 34,46, and the role of the DRN serotonergic system in descending pain modulation and relieving...

既往研究揭示了 DRN 的五羟色胺能神经元在疼痛和抑郁样行为中的作用，该研究发现 DRN 区表达 3 型谷氨酸转运体（ vesicular glutamate transporter 3, VGluT3 ）的神经元投射至 VTA 区多巴胺能神经元的谷氨酸能通路（ VGluT3 DRN→ DA VTA ）在神经病理性疼痛中发生功能下降 ...

研究发现，在慢性疼痛中，DRN→VTA通路的3型谷氨酸转运体（vesicular glutamate transporter 3，VGluT3）神经元发生功能失调，使NAcMed中DA释放特异性改变，干预该神经环路可缓解慢性疼痛的痛觉过敏和CAB症状。

2023年8月23日 · Mechanistically, neuropathic pain dampens VGluT3 DRN → DA VTA glutamatergic transmission and DA VTA neural excitability. VGluT3 DRN → DA VTA activation alleviates neuropathic pain and comorbid anhedonia-like behavior (CAB) by releasing glutamate, which subsequently promotes DA release in the nucleus …

近日，中国科学技术大学张智团队在《Nature Neuroscience》上在线发表题为“A neural circuit for comorbid depressive symptoms in chronic pain”的研究论文，结果揭示了一条5-HTDRN→SOMCeA→GluLHb的神经环路，该新环路可能参与调控CDS发病的某些方面。

2024年9月28日 · This review summarizes the function of specific cell types within DRN in the pain regulation, and aims to improve understanding of the mechanisms underlying pain regulation in the DRN, ultimately offering insights for further exploration.

6 天之前 · The DRN region serves as the primary area for 5-HT neurons and is the main source of serotonergic pathways that are distributed along the trigeminal vascular pain pathway. [ 32 , 45 ] Previous studies have demonstrated that direct electrical stimulation of the vagus nerve can activate this area via neural projections, resulting in the ...

2023年3月23日 · Mechanistically, neuropathic pain dampens VGluT3 DRN →DA VTA glutamatergic transmission and DA VTA neural excitability. VGluT3 DRN →DA VTA activation alleviates neuropathic pain and comorbid depression-like behavior (CDB) by releasing glutamate, which subsequently promotes DA release in the nucleus …