2021年3月31日 · Importantly, the efficacy of PTX-loaded CLs against prostate cancer cells (their IC50 of PTX cytotoxicity) was unaffected by changing the lipid tails, and toxicity of the CL carrier was...

2019年4月15日 · The paclitaxel half-maximal inhibitory concentration (IC50) value for 231-PTX cells was 10.7 nM, which was nearly ten fold higher than that for the 231-WT cells (1.63 nM) (Fig. 1B). After ...

Background Paclitaxel (PTX), a first-line therapy for triple negative breast cancers (TNBC) induces anti-tumor activity by microtubule stabilization and inhibition of cell division.

The IC50 value of PTX, a concentration at which 50% cells are killed, was 1.17 and 0.93 µM for Anzatax® and PTX/TS-CS-PEG-FA micelles, respectively. The in vivo anti-tumor efficacy of PTX/TS-CS-PEG-FA, as measured by reduction in tumor volume of 4T1 mouse breast cancer injected in Balb/c mice was significantly greater than that of Anzatax®.

In this study, a self-augmented reactive oxygen species (ROS) responsive nanocarrier with immunogenic inducer paclitaxel (PTX) and indoleamine 2,3-dixoygenase 1 (IDO1) blocker 1-methyl-d, L ...

Download scientific diagram | Inhibitory concentration (IC 50 ) of PTX in MDA-MB-231 cells. from publication: TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through ...

2023年8月24日 · PTX, as an anti-mitotic drug, is frequently used in the treatment of metastatic breast cancer as first-line therapy that causes mitotic arrest by restaining dynamics of mitotic microtubules [4], which leads to cell death during mitotic arrest or exit mitosis without cell division forming tetraploid cells [5, 6, 7].

结果：3M-052可以明显上调小鼠PBMC分泌的TNF-α；3M-052与PTX单药或联用时均可上调Bax/Bcl-2比例，促进Caspase3活化，增强PARP I蛋白剪切，最终导致细胞凋亡。结论：3M-052或PTX单独使用均可促进CT26细胞凋亡，抑制其增殖，联用时效果更佳。

2017年10月14日 · The IC50 of NLC-PTX (25.33 ± 3.17 nM) was significantly lower than that obtained for free PTX (> 500 nM). These results also suggest that MCF-7 cells were less sensitive to treatment with NLC-PTX compared with MDA-MB-231 cells.

2024年3月6日 · TQ reduced the effective concentration (IC50) of PTX in co-treatment groups. PTX and TQ showed antagonistic effects when cell proliferation declined above 70%. Antagonistic effects shifted into additive and synergistic effects upon increasing PTX concentration, indicated by diminished cell proliferation below 70%.