Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a cytoplasmatic protein encoded by gene PTPN22 and a member of PEST family of protein tyrosine phosphatases. This protein …

2025年3月30日 · PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) is a Protein Coding gene. Diseases associated with PTPN22 include Rheumatoid Arthritis and Systemic …

PTPN22, a member of the protein tyrosine phosphatase (PTP) superfamily that downregulates T cell signaling and proliferation, has recently emerged as a systemically druggable and novel …

编码的蛋白质是一种淋巴细胞特异性细胞内磷酸酶，与分子衔接蛋白 CBL 结合，可能参与调节 T 细胞受体信号通路中的 CBL 功能。 该基因的突变可能与一系列自身免疫性疾病有关，包括 1 …

PTPN22是一种蛋白 酪氨酸 磷酸酶，可通过下调Fyn、Zap-70、LAT等TCR信号通路中的关键蛋白的 磷酸化 水平抑制T细胞的活化。 近年的研究主要集中于PTPN22的 单核苷酸多态性 与Csk …

2022年9月1日 · Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is a protein tyrosine phosphatase that negatively regulates T-cell signaling. However, whether it is expressed and …

2014年7月8日 · PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and functions as a key regulator of immune homeostasis by inhibiting T-cell receptor …

This review describes the basics of PTPN22 structure and function and provides comprehensive insight into recent advances in small molecule PTPN22 inhibitor development and the …

2025年2月8日 · Results provide compelling evidence that the lymphoid-specific phosphatase encoded by PTPN22 is a critical player in multiple autoimmune disorders. Variant R620W of …

PTPN22 encodes a tyrosine phosphatase that is expressed by haematopoietic cells and functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signalling and by …