PTP1B 就是一个广泛存在的原型非受体 酪氨酸磷酸酶，在调节各种代谢如糖尿病肥胖或癌症如 EGF相关通路 中扮演着重要角色。 下面会从它的发现，简单结构，作用机制及作为靶点药物等各个方面简单介绍一下PTP1B这个蛋白磷酸酶。 PTP1B的发现及结构

PTP1B is a negative regulator of the insulin signaling pathway and is considered a promising potential therapeutic target, in particular for treatment of type 2 diabetes. [6] . It has also been implicated in the development of breast cancer and has been explored as a potential therapeutic target in that avenue as well. [7][8][9]

PTP1B专一水解芳香族磷酸，如磷酸化酪氨酸（phosphotyrosyl，pTyr）残基上 磷酸根 的酶，通过对 胰岛素受体 或其底物上的 酪氨酸 残基去磷酸化作用，对胰岛素 信号转导 进行负调节， 组织细胞 中PTP-1B过表达都会降低PTK的活性，使胰岛素受体无法与胰岛素结合 ...

PTP1B, one of the most central protein tyrosine phosphatases (PTPs), is a key player in several human diseases and disorders, such as diabetes, obesity, and hematopoietic malignancies, through modulation of different signaling pathways.

2024年3月22日 · Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signalling pathways, including direct negative...

2024年6月27日 · Protein tyrosine phosphatase 1B (PTP1B) is one of the class I non-receptor tyrosine phosphatases, encoded by the PTPN1 gene. Research on this enzyme began in 1988, after Nicholas K. Tonks et al. isolated this previously unknown …

2022年1月6日 · PTP1B inhibitors improve the sensitivity of the insulin receptor and have the ability to cure insulin resistance-related diseases. We herein summarized the biological functions of PTP1B in different tissues in vivo and in vitro. We also describe the effectiveness of potent PTP1B inhibitors as pharmaceutical agents to treat T2DM.

Overexpression of protein tyrosine phosphatase 1B (PTP1B) disrupts signaling pathways and results in numerous human diseases. In particular, its involvement has been well documented in the pathogenesis of metabolic disorders (diabetes mellitus type ...

Protein-tyrosine phosphatase 1B (PTP1B) has emerged as a key regulator of signaling networks that are implicated in metabolic diseases such as obesity and type 2 diabetes. In this review, we examine mechanisms that regulate PTP1B-substrate interaction, enzymatic activity and experimental approaches to identify PTP1B substrates.

2018年1月1日 · 实验确定了胰岛β细胞中的EphA5是 PTP1B底 物。 以上数据表明,PTP1B可能与胰岛β细 胞的增殖、凋亡以及胰岛素的分泌有着密切联系,因 而抑制PT