The duo created by Oleksii and NK was officially the most popular touring duo in the country. The joint activity of the artists was followed by incredible success and achievements as well as …

NK (natural killer) cells are lymphocytes of the innate immune system. Upon recognition of their target cells, NK cells can either degranulate, releasing various cytotoxic enzymes and …

近期，由多个研究单位的首席科学家领衔，在 Nature 上发表的最新成果—— "The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity" [1]，发现 首个已知的活性位 …

Unrelated inhibitory receptors on B cells have recently been shown to function through recruitment of phosphotyrosine phosphatase 1C (PTP-1C). Here, we show that a human killer inhibitory …

2023年10月4日 · Here we present the discovery and characterization of ABBV-CLS-484 (AC484), a first-in-class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor. AC484 …

In addition to cytotoxic T lymphocyte antigen 4 (CTLA4) and programmed death 1 (PD1), classical ICs of T lymphocytes and recently described also on a fraction of natural killer (NK) cells, …

nk（自然杀伤细胞）是先天免疫系统的淋巴细胞，参与针对外来细胞以及遭受各种形式压力（例如微生物感染（病毒，细菌或寄生虫），肿瘤）的自体细胞的早期防御机制转化或非恶性激活。

2017年10月11日 · Of 77 mammalian phosphatases tested, PTPN1 led to the inhibition of JNK pathway activation. Further analyses revealed that of three pathway member kinases, PTPN1 …

2005年7月12日 · NK (natural killer) cells are lymphocytes of the innate immune system that are involved in early defense mechanisms against foreign cells as well as autologous cells that are …

Evidence show that NK cells quickly kill close by cells that exhibit surface markers related to oncogenic transformation. This activity of NK cells is unique amongst the immune cells. Also, …