Protein tyrosine kinase 7 (PTK7) is an evolutionarily conserved transmembrane receptor and a specialized tyrosine kinase protein lacking kinase activity. PTK7 has been found to be strongly associated with a variety of diseases, including cancer.

2024年5月21日 · Among the so-called pseudotyrosine kinases, the PTK7 receptor tyrosine kinase (RTK) stands as a bona fide target overexpressed in several solid tumors and hematological malignancies...

2025年3月30日 · PTK7 (Protein Tyrosine Kinase 7 (Inactive)) is a Protein Coding gene. Diseases associated with PTK7 include Panic Disorder and Anxiety. Among its related pathways are GPCR Pathway and ERK Signaling.

Protein tyrosine kinase 7 (PTK7) is highly expressed and remains stable throughout chemotherapy, while healthy pediatric tissues show minimal expression. Anti-PTK7 CAR T cells regress preclinical metastatic neuroblastoma in mice, supporting its utility for …

Significance: PTK7 is a potential diagnostic biomarker with predictive value and a promising drug target in cancer. Keywords: Cancer, Cell Polarity, Matrix Metalloproteinase (MMP), Metastasis, Migration, Protein Kinase. It is well established that widely expressed PTK7 is essential for vertebrate tissue morphogenesis.

2020年12月10日 · Protein tyrosine kinase-7 (PTK7), as an important membrane receptor, regulates various cellular activities, including cell polarity, movement, migration, and invasion.

2021年8月12日 · Using in vivo xenograft models of lung cancers with different expression levels of PTK7, systemic delivery of PTK7-CAR2 modified T cells significantly prevented tumor growth and prolonged overall survival of mice.

High PTK7 expression is associated with radioresistance in esophageal squamous cell carcinoma. PTK7 enriches in self-renewing, multipotent stem cells of the human colon. findings implicate PTK7 as a risk factor for NTDs and provide additional evidence for a pathogenic role of PCP signaling in these malformations

2024年9月20日 · Protein tyrosine kinase 7 (PTK7) is a conserved catalytically defective transmembrane receptor that is a potential therapeutic target in triple-negative breast cancer, ovarian cancer, and non-small cell lung cancer.

Protein tyrosine kinase 7 (PTK7) is highly expressed and remains stable throughout chemotherapy, while healthy pediatric tissues show minimal expression. Anti-PTK7 CAR T cells regress preclinical metastatic neuroblastoma in mice, supporting its utility for …