Targeting FAK in anticancer combination therapies - Nature
2021年3月17日 · In mouse skin, YAP and TAZ are required for homeostasis and wound healing; conditional genetic deletion of Ptk2 in mouse skin blocks YAP nuclear translocation following …
挑战肿瘤耐药！FAK的最新研究进展 - 知乎 - 知乎专栏
目前，FAK家族共有两个成员，即PTK2 (FAK)和 Pyk2。 其中，Pyk2蛋白与FAK蛋白有48％的相同氨基酸，这两种激酶都不含SH2和SH3结构，属于非受体酪氨酸激酶。 FAK几乎表达于所有的 …
Hippo component YAP promotes focal adhesion and tumour …
2018年7月28日 · Our study provides evidence that YAP acts as a promoter of focal adhesion and tumour invasiveness via regulating FAK phosphorylation in breast cancer. Further experiments …
Nat Rev Cancer综述: 靶向FAK的抗癌联合疗法 - 知乎
PTK2在HGSOC中被扩增，HGSOC是卵巢癌中死亡率最高的亚型，比其他任何癌症中都要高。 重要的是，在HGSOC中，FAK表达的增加与PTK2的增加是一致的，这与肿瘤进展和不良预后相 …
Exploiting mechanoregulation via FAK/YAP to overcome platinum ...
2024年10月1日 · Mechano-reciprocity has emerged as a crucial factor affecting anti-cancer drug resistance during adjuvant therapy. Here, we investigated the focal adhesion kinase …
IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth …
This engineered experimental model nicely confirmed that FAK is involved in the IGF-1-mediated YAP activation, as IGF-1 failed to decrease S127 YAP phosphorylation (Figure 5E,F) and YAP …
PTK2 Gene - GeneCards | FAK1 Protein | FAK1 Antibody
2025年3月30日 · PTK2 (Protein Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with PTK2 include Glioma Susceptibility 1 and Colon Adenocarcinoma. Among its …
YAP induces FAK phosphorylation to inhibit gastric cancer cell ...
2024年3月1日 · In this study, we present compelling evidence for YAP-TEAD interaction-mediated FAK phosphorylation in gastric cancer cells. YAP overexpression induces robust FAK …
An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based ... - PubMed
2017年7月6日 · Specifically, we identified a pathway involving activation of integrin α3 in TA cells that signals through an LATS-independent FAK/CDC42/PP1A cascade to control YAP-S397 …
Focal adhesion kinase (FAK) promotes cholangiocarcinoma development …
2021年10月1日 · Focal adhesion kinase (FAK), encoded by the PTK2 gene, is a non-receptor protein tyrosine kinase. 2 Overexpression and activation of FAK are associated with the …