Here, we sought definitive in vivo genetic evidence for, and mechanistic understanding of, the essential role of CHD1 in PTEN-deficient prostate cancer. In Pten and Pten/Smad4 genetically …

2017年2月6日 · In addition to known synthetic-lethal interactions, this approach uncovered the chromatin helicase DNA-binding factor CHD1 as a putative synthetic-essential gene in PTEN …

Furthermore, our study identified a novel PTEN pathway linking PTEN and chromatin-mediated regulation of the cancer-relevant NF-κB network. Specifically, mechanistic analyses identified …

2017年2月23日 · Mechanistically, functional PTEN stimulates the GSK3β-mediated phosphorylation of CHD1 degron domains, which promotes CHD1 degradation via the β-TrCP …

2024年11月7日 · CHD1 is a chromodomain-helicase DNA-binding protein that preferentially recognizes di- and trimethylated lysine 4 on histone H3 (H3K4me2/3). Genetic studies have …

2024年4月1日 · Among the epigenetic factors involved in the epigenetic remodeling of chromatin, the chromodomain helicase DNA-binding protein (CHD) family frequently exhibits gain- or loss …

In Pten and Pten/Smad4 genetically engineered mouse models, prostate specific deletion of Chd1 resulted in markedly delayed tumor progression and prolonged survival. Chd1 deletion was …

In Pten and Pten / Smad4 genetically engineered mouse models, prostate-specific deletion of Chd1 resulted in markedly delayed tumor progression and prolonged survival. Chd1 deletion …

However, in PTEN-deficient prostate tumors, the CHD1 protein is stabilized and contributes to cancer progression, tumor microenvironment remodeling, and drug resistance (25 – 27). In …

We previously identified chromodomain-helicase-DNA-binding protein 1 (CHD1) as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive in vivo genetic evidence for, …