PTCH1 is a member of the patched gene family and is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. …

在没有 Hh 配体的情况下，Hh 受体如 Ptch-1，定位于初级纤毛，可以阻止 SMO 积累且抑制 SMO 活性。 蛋白激酶，如 PKA、GSK3β 和 CK1α，磷酸化 GLI2 和 GLI3，导致蛋白体介导全长 …

2025年3月30日 · PTCH1 (Patched 1) is a Protein Coding gene. Diseases associated with PTCH1 include Basal Cell Nevus Syndrome 1 and Holoprosencephaly 7. Among its related pathways …

The PTCH1 gene provides instructions for producing the patched-1 protein, which functions as a receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, …

Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly. Characterisation of human patched germ line mutations in naevoid basal …

2024年12月10日 · Title: Implicating clinical utility of altered expression of PTCH1 & SMO in oral squamous cell carcinoma. TRIM37 interacts with EZH2 to epigenetically suppress PTCH1 and …

Patched1 (PTCH1) is a frequently altered gene in CRCs and its mutations contribute to unregulated Hedgehog (Hh) signaling. In the study, we evaluated the association of PTCH1 …

PTCH1 (NCBI Reference Sequence NM_000264.3) is the human homolog of the Drosophila patched‐1 gene and is located on chromosome 9q22.3. It contains 24 exons with the …

该基因编码修补蛋白家族的一个成员和刺猬信号通路的一个组成部分。 Hedgehog 信号在胚胎发育和肿瘤发生中很重要。 编码的蛋白质是分泌的刺猬配体的受体，刺猬配体包括音速刺猬、印 …

PTCH1 comprises 2 interacting extracellular domains, ECD1 and ECD2, and 12 transmembrane segments, with transmembrane segments 2 to 6 constituting the sterol-sensing domain. Two …