Mechanisms of MAGUK-mediated cellular junctional
2018年2月1日 · The PDZ-SH3-GK (PSG) tandem architecture is evolutionarily conserved from choanoflagelleta, the unicellular ancestor of metazoans, to human (Figure 1 a) [39]. …
Functional interplay between protein domains in a …
2020年2月14日 · How such adjacent domains form supertertiary structures and modulate protein–protein interactions has only recently been addressed and is incompletely understood. …
Mechanistic basis of MAGUK-organized complexes in synaptic
2016年3月18日 · This review comprehensively summarizes the mechanistic bases of complex formation between the extended PDZ domain and the extended PBM, as well as the regulated …
Structure of Crumbs tail in complex with the PALS1 PDZ–SH3 ... - PNAS
2014年11月10日 · We show that the PDZ–SH3–GK (PSG) tandem of PALS1 binds to Crb-CT with ∼100-fold higher affinity than the PDZ domain alone. The structure of the PALS1 …
Crystal structure of ZO-1 PDZ3-SH3-GUK domains. A , structure of ...
ZO-1 PDZ3-SH3-GUK Domains —The polypeptide containing the PDZ3-SH3-GUK (residues 417– 803) tandem domains of ZO-1 crystallized in the P3 2 space group and the diffraction …
Intramolecular domain dynamics regulate synaptic MAGUK …
2019年3月13日 · PSD-95 MAGUK family scaffold proteins are multi-domain organisers of synaptic transmission that contain three PDZ domains followed by an SH3-GK domain tandem. This …
Phase Transition in Postsynaptic Densities Underlies Formation of ...
2016年8月25日 · In this study, we discover that SynGAP, one of the most abundant PSD proteins and a Ras/Rap GTPase activator, forms a homo-trimer and binds to multiple copies of PSD …
涉及突触后密度蛋白PSD-95的超模块结构中的蛋白结构域之间的功 …
突触后密度蛋白PSD-95包含一个称为PSG的三结构域超模块，该模块由PDZ，Src同源性3（SH3）和鸟苷酸激酶样结构域组成。 PDZ结构域与其提议的天然配体的C末端结合，PDZ3 …
PDZ Domains from the Junctional Proteins Afadin and ZO-1 Act as ...
2023年10月23日 · In contrast, the bond between the PDZ3-SH3-GUK (PSG) domain of the cytoskeletal adaptor ZO-1 and the JAM-A intracellular domain becomes dramatically weaker in …
Determinants of affinity, specificity, and phase separation in a ...
2022年10月10日 · Here, we investigated the interactome of a three-domain supramodule, PDZ3-SH3-GK (PSG) from PSD-95 using bioinformatics to identify potential binding partners, and …