Peroxisome proliferator-activated receptors (PPARs) regulate storage and catabolism of fats and carbohydrates. PPARgamma activity increases insulin sensitivity and adipocyte differentiation at the expense of adipogenesis and weight gain. The …

摘 要：脂肪细胞型脂肪酸结合蛋白(a-fabp/fabp4/ap2/albp)作为脂肪酸结合蛋白家族中的一员，在 脂肪细胞和巨噬细胞中高表达。 在鼠及人的肥胖个体中FABP4表达均增加。

Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and implicated in the development of insulin resistance and atherosclerosis. Here we demonstrate that FABP4 triggers the ubiquitination and subsequent pro …

2010年11月3日 · We show that PER2 directly and specifically represses PPARγ, a nuclear receptor critical in adipogenesis, insulin sensitivity, and inflammatory response. PER2-deficient mice display altered lipid metabolism with drastic reduction of total triacylglycerol and nonesterified fatty acids.

2014年2月13日 · A major target gene of PPARγ is the lipid transporter FABP4, also known as aP2 . PPARγ induces FABP4 almost exclusively in adipocytes and macrophages. FABP4 acts as a fatty acids chaperone, which couples intracellular lipids to biological targets and signaling pathways (15,16).

2004年11月1日 · This report presents the cloning strategy of the human adipocyte fatty acid-binding protein (or aP2) gene promoter and its functional characterization based on human PPAR reporter-gene pharmacological assays.

1994年12月30日 · Peroxisome proliferator-activated receptor γ2 (PPARγ2) is an adipocyte-specific nuclear hormone receptor that has recently been identified as a key regulator of two fat cell enhancers. Transcriptional activation by PPARγ2 is potentiated by a variety of lipids and lipid-like compounds, including naturally occurring polyunsaturated fatty acids.

One of the AP2 subunits, adaptor-related protein complex 2, α2 subunit (Ap2a2), has recently been identified as a peroxisome proliferator-activated receptor (PPAR)α target gene. The effects of PPARα on the AP2 adaptor complex and CME are unknown.

2022年4月26日 · Peroxisome proliferator-activated receptor (PPAR)-γ is a key transcription activator controlling adipogenesis and lipid metabolism. PPARγ binds PPAR response...

2019年9月18日 · Our data show that the AP2 complex subunit Ap2a2 is increased in adipocytes with PPARα agonist therapy and is important for efficient endocytosis of β2- and β3-ARs at the plasma membrane to facilitate lipolytic release of fatty acids.