2024年12月25日 · PON1 (Paraoxonase 1) is a Protein Coding gene. Diseases associated with PON1 include Microvascular Complications Of Diabetes 5 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7. Among its related pathways …

Human PON1 is a glycoprotein composed of 354 amino acids and has a molecular weight of 43,000 daltons which associates with high-density lipoprotein (HDL, cholesterol) in the circulation. Serum PON1 is secreted mainly by the liver, although local synthesis occurs in several tissues and PON1 protein is found in almost all tissues.

血清对氧磷酶能够催化磷酸酯键水解，降解有机磷酸酯、芳香羧酸酯和氨基甲酸酯，这是pon1对有机磷化合物中毒保护作用的分子基础。

Paraoxonase-1 (PON1) is a high-density lipoprotein-associated esterase and is speculated to play a role in several human diseases including diabetes mellitus and atherosclerosis. Low PON1 activity has been associated with increased risk of major ...

该基因编码对氧磷酶家族的一个成员，并表现出内酯酶和酯水解酶活性。 在肾脏和肝脏中合成后，该酶被分泌到循环中，与高密度脂蛋白 (HDL) 颗粒结合并水解硫内酯和异生素，包括对氧磷 (杀虫剂对硫磷的一种代谢物) 。 该基因的多态性可能与冠状动脉疾病和糖尿病性视网膜病变有关。 该基因存在于 7 号染色体上的三个相关对氧磷酶基因簇中。 [RefSeq 提供，2017 年 8 月] This gene encodes a member of the paraoxonase family of Enzymes and exhibits lactonase and ester …

Human serum paraoxonase-1 (PON1) is a Ca 2+ dependent high-density lipoprotein (HDL) associated lactonase capable of hydrolysing a wide variety of lactones (including a number of pharmaceutical agents), thiolactones, arylesters, cyclic carbonates and organophosphate pesticides, nerve gases such as sarin and soman, glucuronide drugs and oestrogen...

pon1是hdl中抗氧化作用的主要成分，它能阻止hdl和ldl发生氧化，使hdl促使胆固醇流出的功能增强，从而发挥对动脉粥样硬化的保护作用。 一些研究已证实pon1活性降低是动脉粥样硬化发展的危险因素，它的活性高低并不依赖于hdl的浓度。

Human paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated serum enzyme that exhibits a broad substrate specificity. In addition to protecting against exposure to some organophosphorus (OP) pesticides by hydrolyzing their toxic oxon metabolites, PON1 is important in protecting against vascular disease by metabolizing oxidized lipids.

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. 这个基因编码对氧磷酶家族的一员，并表现出内酯酶和酯酶活性。 在肾脏和肝脏中合成后，该酶被分泌到循环中，与高密度脂蛋白（HDL）颗粒结合，水解硫代内酯和外来物质，包括对氧磷的一种代谢物，对硫磷。 这个基因的变异可能与冠状动脉疾病和糖尿病性视网膜病变有关。 这个基因位于染色体7上一个由三个相关对氧磷酶基因组成的簇中。 [RefSeq，2017 …

对氧磷酶1 (PON1)是一种Ca2+依赖,高密度脂蛋白 (HDL)相关性的内酯酶,它能阻止或抑制低密度脂蛋白 (LDL)的氧化.LDL氧化被认为是动脉粥样硬化起始和进展的中心环节,所以PON1被证实具有动脉粥样硬化保护作用.PON1有多种基因多态性位点,这些多态性引起基因启动子活性的差异,导致基因表达水平和PON1活性的差异,从而影响动脉粥样硬化的形成.重要的是,影响动脉粥样硬化的是PON1的活性,而不是其基因型. 百度学术集成海量学术资源，融合人工智能、深度学习、大数 …