Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare blood disorder characterized by chronic intravascular hemolysis, thromboses in unusual sites and cytopenias related to bone marrow …

2016年12月2日 · Once suspected, the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) is straightforward when flow cytometric analysis of the peripheral blood reveals a population of …

In this document, we present a consensus effort that describes flow cytometric procedures for detecting PNH cells. We discuss clinical indications and offer recommendations on data …

Flow cytometry is the most useful and accepted method to confirm the diagnosis of PNH. Some clinicians also use annual flow cytometry to screen patients with an underlying bone marrow …

2007年2月6日 · PNH is an acquired hematopoietic stem cell disorder leading to a partial or absolute deficiency of all glycophosphatidyl-inositol (GPI)-linked proteins. The classical …

Flow cytometry is the gold standard in diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) by detecting the absence of glycol-phosphatidyl inositol (GPI)-linked protein expression on …

2019年11月25日 · Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare blood disorder characterized by chronic intravascular hemolysis, thromboses in unusual sites and cytopenias …

We investigated the relative merits of the various protocols and determined a recommended strategy for sensitive flow cytometric detection of PNH clones. It has been shown that in the …

Long-term management involves regular monitoring of blood counts, LDH levels, and paroxysmal nocturnal hemoglobinuria (PNH) clone size via flow cytometry. Strategies to prevent and …

2007年9月1日 · Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder closely related to aplastic anemia. Hemolytic anemia and life-threatening …