阵发性睡眠性血红蛋白尿症流式细胞术检测中国专家共识（2021年 …
红细胞上用于pnh检测的锚连蛋白主要是cd59和cd55，由于cd59表达量高，与其他抗原相比，更容易鉴别正常细胞（Ⅰ型细胞）、部分缺失（Ⅱ型细胞）和完全缺失（Ⅲ型细胞）的pnh细胞。
阵发性睡眠性血红蛋白尿症（PNH）的奥秘？ - 知乎专栏
（1）常用的是抗cd55及cd59抗体，加入流式细胞仪后可以与细胞表面cd55及cd59特异性的结合。 未被CD55、CD59结合的细胞即为PNH细胞。 就可以通过显色分析可以确定CD55ˉ、CD59ˉ …
Abnormalities in the expression of CD55 and CD59 surface ... - PubMed
Paroxysmal nocturnal hemoglobinuria (PNH) is a genetic disorder due to the impaired conformation of the glycolsylphosphatidylinositol anchor, which results in the deficient …
Laboratory studies for paroxysmal nocturnal hemoglobinuria, with ...
2020年5月1日 · Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal hematopoietic stem cell disorder caused by somatic mutations in the PIG-A gene, leading to …
ICCS/ESCCA Consensus Guidelines to detect GPI‐deficient cells in ...
To detect GPI-deficient PNH RBC phenotypes, antibodies to CD59 provide the best means to delineate and enumerate PNH type III, PNH type II and normal (type I) RBCs 11, 19. Once …
CD59: Biological function and its potential for drug target action
2023年6月1日 · CD59 regulates immune system and protects cells from complement system. CD59 deficiency is associated with paroxysmal nocturnal hemoglobinuria (PNH). CD59 is …
A belt-and-suspenders approach to PNH | Blood | American …
2025年2月20日 · CD59 inhibits downstream of C5 by regulating terminal complement, and CD55 works upstream of C5 to regulate both the C3 and C5 convertases. Deficient complement …
Identifying Genes Associated With Proliferation, Immunity and ...
CD59+ and CD59- peripheral blood mononuclear cells from seven patients were sorted, and the RNA and protein expression levels of target genes were assessed via quantitative real-time …
CD55和CD59在PNH中的表达及意义 - 道客巴巴
2014年8月22日 · 传统方法可通过糖水试验、 酸溶血试验 ( Ham) 诊断, 但敏感性、特异性较差, 本文应用 流式细 胞仪检测 PNH 患 者 CD55、CD59 抗原 表达的 情况, 将 PNH 与 健康对照 组 …
PNHの診断 | 日本PNH研究会
再生不良性貧血（AA）やMDSの不応性貧血で、溶血症状をきたさない程度のPNH血球を持った患者（subclinical PNH; PNH-sc）の場合、免疫抑制療法の奏功率が高い傾向にあることが提 …