2025年3月30日 · A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).

Phospholipase D 1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, [5] [6] though analogues are found in plants, fungi, prokaryotes, and even viruses. [7]

2020年7月20日 · 三分钟读懂pd1/pd-l1。 1：人体的t淋巴细胞是免疫细胞，能够识别并且杀灭肿瘤细胞；pd-1是t淋巴细胞的调节蛋白，但是抑制淋巴细胞的免疫杀伤左右，好处是避免t淋巴细胞杀伤了正常的人体细胞，弊端是降低了t淋巴细…

Phospholipase D (EC 3.1.4.4, lipophosphodiesterase II, lecithinase D, choline phosphatase, PLD; systematic name phosphatidylcholine phosphatidohydrolase) is an anesthetic sensitive [1] and mechanosensitive [2] enzyme of the phospholipase superfamily that catalyses the following reaction a phosphatidylcholine + H 2 O = choline + a phosphatidate

磷脂酶d（pld）是一种广泛存在于动物、植物和微生物中的酶，具有催化磷脂分解的能力，生成磷脂酸（pa）等重要分子。 PLD在细胞膜的信号转导、囊泡运输及细胞分裂等生理过程中扮演着关键角色。

pld信号通路是细胞内的一种次级信号传递系统，通过pld代谢产物——pa的作用，参与调控多种生物学过程，包括细胞分化、增殖、运动、内质网应激反应以及膜结构、细胞架构的改变等。

2025年1月4日 · PH_PLD; Phospholipase D pleckstrin homology (PH) domain; NM_002662.5 → NP_002653.1 phospholipase D1 isoform a. See identical proteins and their annotated locations for NP_002653.1. Status: REVIEWED. Description Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Source sequence(s)

Clinical activity of programmed cell death 1 (PD-1) blockade in never, light, and heavy smokers with non-small-cell lung cancer and PD-L1 expression >/=50. Phospholipase D1 inhibition sensitizes glioblastoma to temozolomide and suppresses its tumorigenicity.

2020年3月16日 · Here, we present a 1.8 Å-resolution crystal structure of the human PLD1 catalytic domain, which is characterized by a globular fold with a funnel-shaped hydrophobic cavity leading to the active...

Other names: programmed death-ligand 1, PDLI, PDL-1 by immunohistochemistry (IHC) What is it used for? PD-L1 testing is used to look for the PD-L1 protein on cancer cells in a sample of tumor tissue.