Type 1干扰素抗病毒作用机制 - 知乎 - 知乎专栏
ISGs包括PKR；2’-5'-OAS 和RNAse L。 PKR识别ds RNA，然后关闭蛋白表达（PKR识别dsRNA被激活，使eIF2磷酸化，然后其不能发挥翻译起始作用）。 OAS作用（OAS被dsRNA …
干扰素刺激基因的抗病毒机制 - actamicro.ijournals.cn
2018年3月1日 · ISGF3能够入核并结合到ISGs的上游序列干扰素刺激应答元件 (Interferon-stimulated response elements，ISRE)上，诱导ISGs大量转录 (图 1)。 IFN-γ与细胞表面的受体 …
Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB ...
2018年2月5日 · We propose that in response to poly(I:C) stimulation, PKR and OAS1A reduce synthesis of NF-κB-inducible inhibitors, IκBα and A20, leading to stabilisation of NF-κB and …
IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not …
2001年3月23日 · Virus-induced dsRNA activates PKR while a second, protein synthesis-dependent step activates an unknown kinase X which phosphorylates IRF3 and -7. Activated …
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction
2016年3月3日 · To address how PKR may influence the MDA5-MAVS-IRF3 pathway, we found that PKR physically interacted in a complex with MDA5 (Fig 5A, 5B and 5C). This association …
Induction of Protein Kinase PKR-dependent Activation of …
Rapid phosphorylation and nuclear accumulation of IRF-3 were detected in PKR-sufficient cells following infection with E3L deletion mutant (ΔE3L) virus. By contrast, the full IRF-3 activation …
Protein Kinase PKR Amplification of Interferon β Induction Occurs ...
2012年10月19日 · Our findings, taken together, reveal that PKR functions at least in part through an eIF-2-mediated translational control mechanism to indirectly enhance IFN-β transcript …
The role of protein kinase R in the interferon response
The protein kinase R (PKR) is one of the first and best characterized of these effector molecules. PKR mediates responses via phosphorylation of protein substrates and promotes signal …
IRF3 and ERK MAP-kinases control nitric oxide production from ...
2013年9月17日 · We found in macrophages that IRF3, ERK MAP-kinases, and PKR are essential to NO production in response to RNA-virus mimic, poly I:C, a TLR3 agonist. ERK’s role in NO …
The early interferon response to rotavirus is regulated by PKR and ...
IRF3 was found to be essential for MAVS/IPS-1-directed ISG transcription and IFN-β secretion during rotavirus infection. Interestingly, absence of the double-stranded RNA-dependent …