2016年12月2日 · PKR promotes CNV formation via the PI3K/Akt signaling pathway in VEGF expression. Additionally, the anti-PKR monoclonal antibody significantly decreased CNV in a mouse model, showing the antibody may have therapeutic potential in human CNV.

2011年9月27日 · We demonstrate induction of the phosphorylation of eIF2α in mammalian cells after either pharmacological inhibition of the phosphoinositide 3-kinase (PI3K)–Akt pathway or genetic or small interfering RNA–mediated ablation of Akt.

2022年5月6日 · Here we show that PKR signaling involves the assembly of dynamic PKR clusters. PKR clustering is driven by ligand binding to PKR’s sensor domain and by front-to-front interfaces between PKR’s kinase domains. PKR clusters are discrete, heterogeneous, autonomous coalescences that share some protein components with processing bodies.

Akt 途径或PI3K-Akt途径是细胞相应胞外生存和生长的信号的转导途径。 涉及的关键蛋白是PI3K（ 磷脂酰肌醇 3-激酶）和Akt（ 蛋白激酶B ）。 生长因子 的初始刺激引起 细胞表面受体 的激活和PI3K的磷酸化。

2006年8月21日 · Double-stranded RNA-dependent protein kinase (PKR), a ubiquitously expressed serine/threonine kinase, has been implicated in the regulation or modulation of cell growth...

2021年11月19日 · Protein kinase RNA-activated (PKR) plays a critical role in immune response to viral infection. We identified PKR as a phospho-protein in response to anti-tubulin agents...

2019年9月3日 · Moreover, we found that PKR participated in the p53-dependent destruction of AKT following activation of p38 MAPK. The inhibition of AKT led to the reduced expression of PGC-1α, which resulted in mitochondrial dysfunction and increased oxidative stress.

2008年3月1日 · Here, we demonstrate that PKR is an essential component of the muscle development machinery and forms a functional complex with p38MAPK and/or Akt, contributing to muscle differentiation of committed myogenic cells in vitro.

PKR activation with rotenone (10 µM) abrogated endotoxin tolerance by increasing the levels of the IL‑1β, CCL17 and CCL22 mRNAs and decreasing the levels of the Arg1 and iNOS mRNAs. Furthermore, western blotting demonstrated that AKT was markedly inactivated in endotoxin‑tolerant cells, as indicated by reduced p‑AKT levels.

2022年11月24日 · 蛋白激酶r（pkr）样内质网激酶（perk）是四种已知的激酶之一，通过激活真核细胞起始因子2α（eif2α）或其他信号转导级联来响应细胞应激。perk在胰腺β细胞中高度表达，对β细胞的发育、分化和功能至关重要。