PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

2025年3月30日 · PKN3 (Protein Kinase N3) is a Protein Coding gene. Diseases associated with PKN3 include Nonarteritic Anterior Ischemic Optic Neuropathy and Gastrointestinal Neuroendocrine Tumor. Among its related pathways are …

2022年9月14日 · Growing evidence indicates an important role for PKN3 in some cancers, in particular in metastasis; for example, knockout of PKN3 in mice has been shown to inhibit melanoma metastasis (Sci....

2016年1月8日 · Our data provide the first in vivo genetic demonstration that PKN3 plays critical roles in angiogenesis and tumor metastasis and that defective maturation of cell surface glycoproteins might...

Title: PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers.

2016年9月14日 · Gene target information for PKN3 - protein kinase N3 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PKN3 contains 3 N-terminal repeats of a charged region with leucine zipper-like sequences, followed by a domain conserved in other PKN proteins, 2 unique proline-rich regions, and a C-terminal catalytic region with a protein kinase-type ATP-binding sequence.

2022年9月1日 · In this report, an ionizable lipid-based nanoparticles encapsulated with PKN3 shRNA (SS-LNP/shPKN3) were developed with redox-responsiveness to downregulate the overexpression of PKN3 and improve the treatment for breast cancer (Scheme 1). The ionizable lipid was first synthesized by introduction of disulfide bonds.

2004年7月5日 · Contributes to invasiveness in malignant prostate cancer. Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation. Showing features for binding site, active site. Gene Ontology (GO) annotations organized by slimming set. Search…