2013年11月7日 · Here, we report that PKM2 is acetylated by p300 acetyltransferase at K433, which is unique to PKM2 and directly contacts its allosteric activator, fructose 1,6 …

2019年2月20日 · The PKM2 K433E succinylation mimic mutant increased mitochondrial PKM2, and we therefore compared NADH oxidation in HCT116 cells with K433E or ectopic …

2023年3月10日 · Using structure simulation and Co-IP assays, we showed that PHGDH directly facilitates p300 to interact with and acetylate PKM2 at K433, which promotes PKM2 …

2013年11月7日 · We propose that during active cell proliferation or oncogenic transformation, PKM2 is acetylated at K433 by p300 acetyltransferase, which blocks FBP binding and thereby …

Acetylation-mimetic PKM2(K433) mutant promotes cell pro-liferation and tumorigenesis. K433 acetylation is decreased by serum starvation and cell-cell contact, increased by cell cycle …

2013年10月12日 · 研究人员发现，模拟乙酰化作用的pkm2(k433)突变体可促进细胞增殖和肿瘤形成。 通过血清饥饿和细胞间接触可以降低K433乙酰化，而在乳腺癌中刺激细胞周期、表皮生 …

2011年12月1日 · Here we demonstrate, in human cancer cells, that epidermal growth factor receptor (EGFR) activation induces translocation of PKM2, but not PKM1, into the nucleus, …

Here, we report that PKM2 is acetylated by p300 acetyltransferase at K433, which is unique to PKM2 and directly contacts its allosteric activator, fructose 1,6-bisphosphate (FBP). …

2015年1月28日 · The oncogenic E7 protein derived from human papilloma virus induces acetylation of PKM2 at K433, which inhibits FBP binding and thus the stable transition of …

2013年12月10日 · Major finding: Acetylation of PKM2 on K433 promotes its nuclear localization and protein kinase activity. Mechanism: Acetylation of a residue specific to PKM2 prevents its …