2011年11月3日 · We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibition of the glycolytic enzyme pyruvate kinase M2 (PKM2) …

2024年2月8日 · When the intracellular ROS concentration increases, the cysteine at position 358 of PKM2 will be oxidized and the activity of PKM2 will be reduced. This causes glucose to be …

Oxidation of PKM2 at cysteine-358 confers an advantage to cancer cells, as it allows the cells to withstand ROS . Intracellular ROS-induced oxidation of cysteine-358 decreases the activity of …

2019年11月1日 · EGFR/ERK2-dependent PKM2 phosphorylation or oxidation of the sulfhydryl group of cysteine-358 (C-358) inhibited PKM2, and it was proposed to promote PKM2 nuclear …

Low PKM2 activity, in conjunction with increased glucose uptake, facilitates the flux of glucose carbons into anabolic pathways derived from glycolysis 3,9,17,18. Also, PKM2, but not PKM1, …

2013年10月10日 · Acute increases in intracellular ROS inhibit PKM2 activity through oxidation of PKM2 cysteine 358, which diverts glucose flux to the pentose phosphate pathway and thus …

the glycolytic enzyme pyruvate kinase M2 (PKM2) through oxidation of Cys358. This inhibition of PKM2 is required to divert glucose flux into the pentose phosphate pathway and thereby …

2013年5月8日 · PKM2 is directly oxidized on Cys 358 to inhibit its catalytic activity, which allows for diversion of glucose-6-phosphate into the pentose phosphate pathway. This, in turn, allows …

We show that, in human lung cancer cells, acute increases in intracellular concentrations of ROS caused inhibition of the glycolytic enzyme pyruvate kinase M2 (PKM2) through oxidation of …

摘要：pkm2在肿瘤组织中高度表达，对肿瘤的代谢与形成发挥重要作用，目前已成为临床. 上靶向抗肿瘤药物治疗新的有效靶点。本文按pkm2抑制剂的发现途径将其分为三类：基. 于pkm2与 …