PKL-IN-1 是一种丙酮酸激酶 (PKL) 的强效抑制剂， IC50 为 0.07 μM。 PKL-IN-1 可用于非酒精性脂肪性肝病的研究。

PKL-IN-1 (Compound 12a) is a potent pyruvate kinase L (PKL) inhibitor with IC50 values of 0.07 μM and 0.18 μM for PKL and PKR subtypes, respectively. PKL-IN-1 can inhibit 96.6% PKL activity at 10 μM concentration.

2021年10月14日 · Pkl-IN-1 | C12H8O8S | CID 171364345 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

First game was played on July 26 between U Mumba and Jaipur Pink Panthers and the final was played on August 31 at Sardar Vallabhbhai Patel Indoor Stadium, Mumbai. Jaipur Pink Panthers beat U Mumba by 35–24 to win the inaugural Pro Kabaddi League. [1]

2017年5月31日 · Through forward genetic screens we identified PKL, a gene required for developmental regulation in plants, as a factor promoting transcriptional silencing at the transgenic RD29A promoter. Mutation of PKL results in DNA methylation changes at more than half of the loci that are targeted by RNA-directed DNA methylation (RdDM).

2024年11月22日 · ELEVATE YOUR GAME: the PKL-1 Pickleball Paddle is engineered for performance with a Polypropylene honeycomb core that offers optimal balance, durability, and flexibility

The result showed that the chlorophyll content in the pkl-1 mutant was slightly reduced under normal conditions but was substantially decreased under chilling conditions compared to the wild type...

PKL-IN-1（化合物 12a）是丙酮酸激酶 (PKL) 的强效抑制剂，PKL 和 PKR 异构体的 IC50 值分别为 0.07 μM 和 0.18 μM。 PKL-IN-1 在 10 μM 浓度下可抑制 96.6% 的 PKL 活性。

PKL-IN-1 (Compound 12a) is a potent inhibitor of pyruvate kinase (PKL) with IC50 values of 0.07 μM and 0.18 μM for PKL and PKR isoforms, respectively. PKL-IN-1 inhibits 96.6% of PKL activity at a concentration of 10 μM.

2009年8月14日 · Here we show that the CHD3 proteins PICKLE and PICKLE RELATED2 (PKR2) have trxG-like functions in plants and activate PcG protein target genes. Lack of PKL function can partially suppress PcG mutant leaf and flower phenotypes, supporting the idea that CHD3 proteins and PcG proteins act antagonistically during plant development.