Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in …
2019年5月18日 · Schematic view of PKCα inhibitory activity on the Wnt/β-catenin signaling pathway in the normal colon epithelium and in colon cancer. In normal tissue, when the …
Wnt/β-Catenin信号通路 - 知乎
Wnt 配体是一种分泌型糖蛋白，可结合 Frizzled (卷曲）受体，然后与 LRP5/6 一起在细胞表面形成一个更大的复合体。 卷曲受体被 ZNRF3 和 RNF43 泛素化，二者的活性可通过 R-spondin 结 …
Wnt信号通路（主要基因/通路基因分类/信号通路图 - 知乎
2023年10月11日 · Wnt信号通路是一种复杂的信号转导系统，能够参与调控生物体内多种细胞命运决定、细胞增殖和分化等重要生物学过程。 以下是Wnt信号通路中的主要基因介绍。 Wnt信号 …
Protein kinase C in Wnt signaling: implications in cancer ... - PubMed
PKC is one of the key targets of noncanonical Wnt signaling, particularly in the Wnt/Ca (2+) pathway. Recently, data have implicated components of noncanonical Wnt/Ca (2+) and …
RORα Attenuates Wnt/β-Catenin Signaling by PKCα-Dependent ...
2010年1月29日 · Here we identify a specific mechanism of orphan nuclear receptor RORα-mediated inhibition of canonical Wnt signaling in colon cancer. Wnt5a/PKCα-dependent …
Detecting PKC phosphorylation as part of the Wnt/calcium …
Here we summarize the current understanding of the Wnt/Calcium pathway and discuss methods of detecting activated/phosphorylated PKC as a result of Wnt signaling in malignant …
Protein-kinase-C-mediated beta-catenin phosphorylation …
2006年11月15日 · Here we present small-molecule-based identification of protein kinase C (PKC)-mediated beta-catenin phosphorylation as a novel mechanism regulating the Wnt/beta …
Protein kinase C delta negatively modulates canonical Wnt ... - PubMed
The tumor suppressor Adenomatous Polyposis coli (APC) gene is mutated or lost in most colon cancers. Alterations in Protein kinase C (PKC) isozyme expression and aberrant regulation …
Wnt and calcium signaling: β-Catenin-independent pathways
2005年9月1日 · First, specific Wnt and frizzled homologs can activate calcium/calmodulin-dependent kinase II (CamKII) and protein kinase C (PKC) in a Wnt/calcium pathway. Second, …
Wnt信号通路浅谈 - 知乎专栏
在胚胎发育中，Wnt基因调控的重要信号传导系统即为Wnt通路。 Wnt可以分为 经典Wnt途径 （Canonical pathway）， 非典型平面细胞极性途径 （Planar cell polarity pathway），和 非经 …
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