The Role of PKC-MAPK Signalling Pathways in the Development …
2022年8月2日 · In this review, we discuss the recent discovery on the role of PKC-MAPK pathways, the mechanisms involved in the development and progression of diabetic cardiovascular complications, and their potential as therapeutic targets for cardiovascular management in diabetic patients.
经典信号通路总结——MAPK信号通路 - 知乎 - 知乎专栏
mapk通路有4种主要的分支路线： erk 、 jnk 、 p38 /mapk和erk5。 其中，JNK和p38功能相似，跟炎症、凋亡、生长都有关；ERK主要管细胞生长、分化，其上游信号是著名的 Ras/Raf 蛋白。
MAPK signal pathways in the regulation of cell proliferation in ...
2002年3月1日 · Mitogen-activated protein kinase (MAPK) cascades have been shown to play a key role in transduction extracellular signals to cellular responses. In mammalian...
PKC 通路 | Cell Signaling Technology
非典型酶（aPKC；PKCζ 和 PKCι/λ 亚型）含有一个无功能性 C1 区域且缺乏 C2 区域，无需结合第二信使来激活 aPKC。 PDK1 或相关酶负责 PKC 的激活。 PKC 活性的控制通过三个独立的磷酸化事件进行调节。 在体内，磷酸化发生在活化环中的苏氨酸 500 位点，自磷酸化的苏氨酸 641 位点，和羧基末端的疏水性丝氨酸 660 位点。 Study the PKC pathway's role in cellular signaling and regulation. Explore the molecular mechanisms & signaling events governed by this pathway. …
比较G蛋白耦联受体介导的几种信号通路之间的异同？ - 知乎
pkc系统 在G蛋白偶联系统的信号转导中，除了通过cAMP作为第二信使外，磷脂酰肌醇也作为第二信使，此途径称为磷脂酰肌醇信号途径。 该通路也称IP3、DAG、Ca2＋信号通路，或称PKC系统。
TRPM2 promotes pancreatic cancer by PKC/MAPK pathway
2021年6月7日 · TRPM2 may directly activate PKCα by calcium or indirectly activate PKCε and PKCδ by increased DAG in PA, which promote PA by downstream MAPK/MEK pathway activation. Pancreatic cancer is...
The Role of PKC-MAPK Signalling Pathways in the Development …
2022年8月2日 · In this review, we discuss the recent discovery on the role of PKC-MAPK pathways, the mechanisms involved in the development and progression of diabetic cardiovascular complications, and their potential as therapeutic targets for cardiovascular management in diabetic patients.
PKC-mediated phosphorylation and activation of the MEK/ERK
2022年10月18日 · MAPK (ERK) pathway activation was common to both intrinsic and acquired resistance cellular models. The overexpression of upstream RAS/RAF, however, was confined to JIMT 1; meanwhile, in a cellular model of acquired trastuzumab resistance generated in this study (T15), entry into the ERK pathway seemed to be mostly mediated by PKCα activation.
快速了解ERK/MAPK信号通路？ - 知乎专栏
丝裂原活化蛋白激酶（mapk）级联是调节细胞多种生理过程的关键信号通路，包括增殖、分化、凋亡和应激反应。 在真核细胞中已经确定了以下四条MAPK级联途径：ERK、JNK、p38 MAPK和ERK5信号转导途径。
层层进击的磷酸化信号—MAPK通路解析 (下) - 知乎
这类mapk通路可以由两种小g蛋白rac和cdc42介导。活化的cdc42结合并活化pak1/2蛋白激酶。活化的pak1/2能激活mekk，mekk接下来在219位和223位丝氨酸位点磷酸化 mkk7 。活化的mkk7磷酸化jnk的tpy结构域。