2025年3月30日 · Complete information for PIM2 gene (Protein Coding), Pim-2 Proto-Oncogene, Serine/Threonine Kinase, including: function, proteins, disorders, pathways, orthologs, and …

Serine/threonine-protein kinase Pim-2 is an enzyme that in humans is encoded by the PIM2 (Proviral Integrations of Moloney virus 2) gene. [5][6] The enzyme is a serine/threonine kinase …

PIM2 (proviral integration site for Moloney murine leukemia virus 2) kinase plays an important role as an oncogene in multiple cancers, such as leukemia, liver, lung, myeloma, prostate and …

PIM2 is calculated from the information collected at the time a child is admitted to your ICU. Because PIM2 describes how ill the child was at the time you started intensive care, the …

2025年2月8日 · PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-kappaB signaling pathway. TRAF3 regulates the oncogenic proteins Pim2 and c …

We now report on a new non-ATP competitive PIM2-selective inhibitor JP11646 with potent anti-MM activity that in addition to inhibition of PIM kinase enzymatic activity has a novel …

2025年2月26日 · In this study, we demonstrated that multiple metabolic enzymes are activated upon Pim2 upregulation during M1 macrophage polarization. Specifically, Pim2 directly …

2016年8月26日 · Our data provide evidence for a novel role for Pim2 in the regulation of the DNA damage response (DDR). Knockdown of Pim2 upregulates several downstream DDR markers, …

These studies have identified a novel PIM2-selective non-ATP competitive inhibitor (JP11646) that has a 4 to 760-fold greater suppression of MM proliferation and viability than ATP …

2020年7月2日 · In this study, we found that regulated by TNFα, Pim-2 proto-oncogene, serine/threonine kinase (PIM2) was highly expressed in HCC and correlated with poor …