2020年3月15日 · In cells, arachidonic acid is transformed into PGE2 via cyclooxygenase (COX) enzymes and terminal prostaglandin E synthases (PGES). Accumulating data suggest that the …

A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF 2α , fluprostenol, and travoprost guided by biocatalytic retrosynthesis. Chemical Science …

Prostaglandin E2 (PGE2), an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of PGE2 reflects the balance …

2006年6月1日 · In this review, we summarize the synthesis and secretion of PGE 2. In particular, we focus on the three isoforms of the terminal PGES, and discuss the potential of targeting …

Their synthesis is initiated by phospholipases (PLAs), a family of enzymes that catalyze the hydrolysis of membrane phospholipids at the sn-2 position, liberating free fatty acids, including …

PGE2 synthase (PGES) catalyzes conversion of COX-derived PGH2 to PGE2. It now appears that there are at least three distinct types of PGES in mammals. We identified two distinct …

2005年10月10日 · Increasing evidence suggests that cyclooxygenase-2 (COX-2) is involved in synaptic transmission and plasticity, and prostaglandin E2 (PGE2) is a key molecule in COX-2 …

Prostaglandin E2 (PGE2) is one of the main catabolic factors involved in OA. Its synthesis is the result of cyclooxygenase (COX) and prostaglandin E synthase (PGES) activities whereas …

2024年10月1日 · Prostaglandin E 2 (PGE 2) is a metabolite of arachidonic acid that belongs to the class of polyunsaturated fatty acids (PUFA) and is synthesized via the cyclooxygenase (COX) …

PGE2 synthesis and signaling pathways. Arachidonic acid (AA) is liberated from membrane phospholipids by catalysis of phospholipase A2 (PLA2), subsequently converted into PGH2 via …