溶质载体家族成员SLC7A11（Solute Carrier Family 7 Member 11，又名xCT）是溶质转运第7家族的第11个成员，其编码的SLC7A11蛋白是胱氨酸/谷氨酸反向转运体（System Xc-）的关键组成部分。

2019年1月8日 · 在肿瘤干细胞（CSC）中，xCT促进CSC表面标记蛋白的表达，与维持CSC的干性特征密切相关，是肿瘤治疗的潜在靶点之一，并且有望应用于肿瘤的临床筛查。 现通过回顾近年来xCT的相关研究，就xCT在肿瘤和CSC中的生物学作用及其作用机制进行综述。

2015年8月1日 · Here, we provided evidence that the expression of xCT, the light chain subunit of system xc−, is regulated by NRF2 in representative human breast cancer cells. Hydrogen peroxide (H 2 O 2) treatment increased nuclear translocation of NRF2, also increasing levels of xCT mRNA and protein and extracellular glutamate release.

System x c -胱氨酸/谷氨酸逆向转运蛋白，由轻链亚基（xCT，SLC7A11）和重链亚基（CD98hc，SLC3A2）组成，主要负责胱氨酸的细胞摄取以换取细胞内谷氨酸。 近年来，已发现 xCT 分子在各种类型癌症的肿瘤生长、进展、转移和多药耐药性中发挥重要作用。

In this review, Liu and colleagues discussed the critical role of xCT cystine/glutamate transporter in regard to redox signaling and cancer metabolism, the molecular mechanisms regulating xCT expression, and the potential therapeutic implications of targeting this transporter for efficacious cancer treatment. Main Text

2023年9月29日 · Solute Carrier Family 7 member 11 (SLC7A11) is a key gene involved in redox regulation in cancer cells and codes for the multipass transmembrane protein xCT. xCT dimerizes with the transmembrane chaperone protein SLC3A2 to form the amino acid transport system xc − …

2020年8月4日 · Cystine/glutamic acid reverse transporter (System X c−), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11), which promotes cystine uptake and glutathione biosynthetic, thus protecting against ...

The cystine/glutamate antiporter xCT is a tumor-associated antigen that has been newly identified in many cancer types. By participating in glutathione biosynthesis, xCT protects cancer cells from oxidative stress conditions and ferroptosis, and ...

2011年2月1日 · Background: The plasma membrane xCT cystine-specific subunit of the cystine/glutamate transporter contributes to chemotherapy resistance in pancreatic cancer by regulating intracellular glutathione levels and protecting cancer cells against oxidative stress.

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