2025年3月30日 · PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) is a Protein Coding gene. Diseases associated with PFKFB3 include Colon Adenocarcinoma and …

PFKFB3 levels affect angiogenesis through mediating VEGF activity, where PFKFB3 upregulation results in enhanced VEGF activity. Moreover, silencing of PFKFB3 impairs angiogenesis, …

2017年11月24日 · In this review, we summarize current knowledge of PFKFB3 regulation by several signal pathways and its function in cancer development in different cell types in cancer …

PFKFB3 is an essential target of EGFR signaling and that PFKFB3 activation is required for glycolysis stimulation upon EGFR activation. PFKFB3 has a key role in mediating glucose …

PFKFB3 has high kinase activity, promotes F2, 6BP synthesis, and then activates PFK-1, increasing glycolysis for cell proliferation. Moreover, PFKFB3 can enter the nucleus to promote …

2018年2月6日 · Here we show that chemotherapeutic agent cisplatin promotes glycolysis, which is suppressed by PFKFB3 deletion. Mechanistically, cisplatin induces PFKFB3 acetylation at …

2014年7月17日 · In this study, we demonstrate that siRNA silencing of endogenous PFKFB3 inhibits Cdk1 activity, which in turn stabilizes p27 protein levels causing cell cycle arrest at …

2013年3月1日 · PFKFB3 has the highest Kinase/Bisphosphatase activity ratio (K/B=700) which promotes high concentrations of Fru-2,6-P2. PFKFB3 protein consists of two homodimeric …

Gene Ontology (GO) annotations organized by slimming set. Showing features for mutagenesis. 20-fold decrease in Km for ATP and 3-fold decrease in Km for fructose-6 phsphate. Loss of …

2023年8月18日 · Our study demonstrates that tubular 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3)–induced lactate accumulation results in elevated histone H4 lysine …