Phosphofructokinase-2 (6-phosphofructo-2-kinase, PFK-2) or fructose bisphosphatase-2 (FBPase-2), is an enzyme indirectly responsible for regulating the rates of glycolysis and gluconeogenesis in cells.

Phosphofructokinase (PFK) is a kinase enzyme that phosphorylates fructose 6-phosphate in glycolysis.

2019年8月6日 · PFK-2 converts Fructose-6-phosphate to Fructose-2,6,-Bisphosphate, which is an allosteric regulator for PFK-1 (an enzyme in glycolysis) and F-1,6-BP (an enzyme in gluconeogenesis). Fructose-2,6-Bisphosphate activates PFK-1 in glycolysis.

2005年8月22日 · The concentration of F2,6BP depends on the activity of the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase). Four genes encoding PFK-2/FBPase have been identified and termed PFKFB1 to PFKFB4. PFKFB3 protein is expressed in high levels in human tumors in situ. The purpose of this study was to determine …

2005年12月1日 · 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase) catalyzes the synthesis and degradation of fructose 2,6-bisphosphate (F2,6BP), which is a powerful activator of 6-phosphofructo-1-kinase, the rate-limiting enzyme of glycolysis.

2004年4月1日 · PFK-2/FBPase-2 modulates intracellular levels of fructose-2,6-bisphosphate (F-2,6-P 2), a highly potent regulator of carbohydrate metabolism (27–29). In liver, the PFK-2/FBPase-2 enzyme is modulated by phosphorylation and dephosphorylation, which significantly affects the kinase/bisphosphatase ratio of this bifunctional enzyme (28,29).

2018年4月4日 · PFK2 is activated to indirectly increase the rate of glycolysis by increasing the slowest step in glycolysis (rate limiting) - PFK1. Think of it like a nitro boost - when needed, it is turned on and boosts the whole glycolysis pathway (via fructose 2,6 bisphosphate as mentioned by the other poster). What is the difference between PFK1 vs PFK2?

Die Phosphofructokinase-2 (PFK-2) ist eine Domäne des bifunktionellen Enzyms PFKFB ("Tandemenzym"). PFKFB besitzt eine weitere Domäne, die Fructose-2,6-bisphosphatase (FBPase2) und eine kleine regulatorische Domäne am N-Terminus.

La enzima bifuncional fosfofructoquinasa 2 / fructosa-bisfosfatasa 2 es responsable de la síntesis y degradación de la fructosa-2,6-bisfosfato, que regula la actividad de las enzimas fosfofructoquinasa 1 y fructosa-bisfosfatasa 1, responsables a su vez de controlar la glucólisis y la gluconeogénesis.

2005年7月1日 · Hepatic glucokinase is regulated by a 68-kDa regulatory protein (GKRP) that is both an inhibitor and nuclear receptor for glucokinase. We tested the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK2) in regulating …