mPEG-PLA and PLA-PEG-PLA copolymeric nanoparticles with three different PLA to PEG ratios are synthesized and used for encapsulation of recombinant human Growth hormone (rhGH). The structure and composition of the synthesized copolymers were …

As a research focus in recent years, polyethylene glycol–polylactic acid (PEG–PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability.

Tri-block poly (lactide) poly(ethylene glycol) poly(lactide) (PLA–PEG–PLA) copolymers are among the most attractive nano-carriers for gene delivery into mammalian cells, due to their biocompatibility and biodegradability properties. However, the low ...

2014年6月10日 · In the paper, we begin by describing polyethylene glycol–poly lactic acid-co-glycolic acid (PEG–PLGA) which was chosen as a typical model copolymer for the construction of nano-sized drug delivery systems and also the types of PEG–PLGA copolymers that were eluted.

2018年3月7日 · Particularly, poly(ethylene glycol)–polylactide (PEG–PLA) micelles have been considered as one of the most promising platforms for drug delivery. The PEG shell effectively prevents the adsorption of proteins and phagocytes, thereby evidently extending the blood circulation period.

PEG-PLA is an amphiphilic AB diblock copolymer. The two blocks are hydrophilic block polyethylene glycol (PEG) and hydrophobic block polylactic acid or polylactide (PLA). The PEG segment is capped with a methyl ether group (i.e. mPEG). The hydrophobic PLA block terminates with a hydroxyl group.

2016年12月15日 · Copolymers of lactic and glycolic acids with poly (ethylene glycol) (PEG) provide thermo-responsive hydrogels.

2018年6月29日 · mPEG-PLA and PLA-PEG-PLA copolymeric nanoparticles with three different PLA to PEG ratios are synthesized and used for encapsulation of recombinant human Growth hormone (rhGH). The...

2023年6月1日 · FRET-PEG-scPLA with in vivo ratiometric imaging reported that short-chain-PLA-PEG copolymers are rapidly hydrolyzed. Biodegradable and biocompatible polymer materials with tunable physical properties present a great interest for controlled drug delivery applications.

2010年11月26日 · As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability.