Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. [5][6][7][8] PECAM-1 plays a key role in …

2025年3月30日 · PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with PECAM1 include Angiosarcoma and Hemangioma. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. An important paralog of this gene is FCRL5.

PECAM-1(CD31) hemophilic interaction up-regulated α6β1 on transmigrated neutrophils in vivo and play a functional role in the ability of α6 integrins to mediate leukocyte migration through the perivascular basement membrane [J].

2007年9月13日 · As well as exhibiting adhesive properties, PECAM-1 is an efficient signaling molecule and is now known to have diverse roles in vascular biology including roles in angiogenesis, platelet function, and thrombosis, mechanosensing of endothelial cell response to fluid shear stress, and regulation of multiple stages of leukocyte migration through ve...

2020年12月13日 · 血小板内皮细胞粘附分子-1（pecam-1），又称cd31抗原，是相对分子质量为130kda左右i型跨膜糖蛋白，为免疫球蛋白超家族细胞粘附分子中的一种, 可在内皮细胞、循环的血小板、单核细胞、中性细胞及t细胞亚群表面表达，是参与血小板黏附和聚集的关键因子,科研 ...

The purpose of this article is to describe the function of the vascular cell adhesion and signaling molecule, PECAM-1, in endothelial cells, with special emphasis on its role in maintaining and restoring the vascular permeability barrier following ...

PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane domain and a 118 amino acid cytoplasmic domain that becomes serine and tyrosine phosphorylated upon cellular activation.

PECAM-1, an adhesion molecule, affects cell proliferation via accumulation of transcriptionally active beta-catenin; PECAM-1 and Fc gamma RIIa are colocalized on the platelet membrane and PECAM-1 down-regulates Fc gamma RIIa-mediated platelet responses.

CD31 (PECAM-1) is platelet endothelial cell adhesion molecule-1, serves as the endothelial cell-specific receptor of clostridium perfringens b-Toxin (CPB). CD31 is also an ER-MP12 antigen, acts as a linker between mechanical stress, metabolism and inflammation.

1997年8月1日 · Its cellular distribution and ability to mediate adhesive and signaling phenomena suggested that PECAM-1 was a multifunctional vascular cell adhesion molecule involved in leukocyte-endothelial and endothelial-endothelial interactions.