Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. [5] [6] It codes for an isozyme of pyruvate …

PDK4 is up-regulated in normal mucosa of patients with colorectal cancer (CRC), and down-regulation of PDK4 in human colon cancer cells reduces cell migration and invasion, and …

Mar 30, 2025 · PDK4 (Pyruvate Dehydrogenase Kinase 4) is a Protein Coding gene. Diseases associated with PDK4 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …

We explored if upregulated mRNA expression of the mitochondrial enzyme pyruvate dehydrogenase kinase 4 (PDK4) may be used as a surrogate marker of increased …

Oct 30, 2023 · Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. Senescent cells display a PDK4 …

Nov 25, 2023 · Pyruvate dehydrogenase kinase 4 (PDK4), a key enzyme regulating energy metabolism, has been implicated in modulating cellular senescence and fibroblast function....

该基因是 PDK/BCKDK 蛋白激酶家族的成员，编码具有组氨酸激酶结构域的线粒体蛋白。 该蛋白质位于线粒体基质中，通过磷酸化其一个亚基来抑制丙酮酸脱氢酶复合物，从而有助于调节葡 …

High PDK4 expression is associated with hepatocellular cancer. upregulation of PDK4 promotes vascular calcification by increasing osteogenic markers with no adverse effect on bone …

Feb 5, 2010 · PDK4 is a key regulator of PDC activity, pyruvate oxidation and glucose homeostasis (Sugden and Holness, 2003, Harris et al., 2002).

Here, we examined the regulation of Pdk4 gene expression by the CCAAT/enhancer-binding protein β (C/EBPβ). C/EBPβ modulates the expression of multiple hepatic genes including …