PDK4 - Wikipedia
Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. [5] [6] It codes for an isozyme of pyruvate …
Nature Metabolism | 新知识：糖代谢调控因子影响肿瘤生长和生理 …
这篇文章于2023年10月发表在 Nature Metabolism （IF=20.8， PDK4 -dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy），是 …
PDK4 Gene - GeneCards | PDK4 Protein | PDK4 Antibody
2025年3月30日 · PDK4 (Pyruvate Dehydrogenase Kinase 4) is a Protein Coding gene. Diseases associated with PDK4 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …
Pyruvate dehydrogenase kinases (PDKs): an overview toward …
PDK4 is up-regulated in normal mucosa of patients with colorectal cancer (CRC), and down-regulation of PDK4 in human colon cancer cells reduces cell migration and invasion, and …
Cell Metabolism | 细胞代谢的分子机制如何做？代谢顶刊CM的这篇 …
PDK不同剪切异构体中，PDK4显著促进EMT，PDK3对EMT有一定的促进作用，而PDK1和PDK2对EMT没有影响（图2C-D）。 作者在PDK4启动子区找到了四个TGF-β信号通路转录因 …
Upregulated PDK4 expression is a sensitive marker of increased fatty ...
We explored if upregulated mRNA expression of the mitochondrial enzyme pyruvate dehydrogenase kinase 4 (PDK4) may be used as a surrogate marker of increased …
丙酮酸脱氢酶激酶 4（PDK4）基因 | MCE - MCE-生物活性 ...
该基因是 PDK/BCKDK 蛋白激酶家族的成员，编码具有组氨酸激酶结构域的线粒体蛋白。 该蛋白质位于线粒体基质中，通过磷酸化其一个亚基来抑制丙酮酸脱氢酶复合物，从而有助于调节葡 …
PDK4 rescues high-glucose-induced senescent fibroblasts and
2023年11月25日 · Pyruvate dehydrogenase kinase 4 (PDK4), a key enzyme regulating energy metabolism, has been implicated in modulating cellular senescence and fibroblast function....
延寿29.6%！中科院孙宇团队：搞定它，帮助葡萄糖代谢重回正 …
2023年11月14日 · 研究者们很快就怀疑到了丙酮酸脱氢酶激酶同工酶4（pdk4）身上。 简单来说，PDK4是PDK家族的一员，能够抑制丙酮酸脱氢酶（PDH）的活性，促进葡萄糖从线粒体氧 …
PDK4-dependent hypercatabolism and lactate production of …
2023年10月30日 · Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. Senescent cells display a PDK4 …