丝氨酸/苏氨酸激酶 AKT（又称作蛋白激酶 B 或Protein kinase B, PKB）作为一种原癌基因，已经成为医学界主要的关注热点，这是因为它在调控各种不同细胞功能（包括代谢、生长、增殖、存活、转录以及蛋白质合成）方面发挥重要作用。 前文提到（上期文章： 《 PI3K-AKT通路专题解析（上）》）， AKT的上游激活剂 PDK1可以在 AKT 的苏氨酸 308 位点将其磷酸化，导致 AKT 的部分激活。 除PDK1之外，AKT还可以被其他一系列基因调控（下图作图的kegg通路图）。 例 …

Mar 30, 2025 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease. Among its related pathways are Regulation of pyruvate metabolism and ESR-mediated signaling.

PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways activated by several growth factors and hormones including insulin signaling.

Apr 6, 2022 · PDK1 (3-phosphoinositide-dependent kinase 1) is a serine/threonine-protein kinase that plays a central role in regulating cell growth, survival, and proliferation. Knocking out PDK1 in...

Nucleus-located PDK1 regulates growth, invasion and migration of breast cancer cells. These findings highlight the potential use of PGK1 mRNA level, PGK1 promoter hypomethylation, and PGK1 pS203 and PDHK1 pT338 levels as biomarkers for cancer progression and prognosis, and the promising significance of PGK1 as a target in cancer treatment.

PDK1, as an important direct target for metabolism, inhibits pyruvate flux to mitochondrial respiration. A rescue of PDK1 expression in Wnt-inhibited cancer cells rescues glycolysis as well as vessel growth in the tumor microenvironment [79,80].

PDK-1 是 PI3K 通路中的关键节点，通过磷酸化和随后激活许多其他 AGC 激酶家族成员（如蛋白激酶 B），在胰岛素和生长因子信号传导中发挥关键作用。 PDK-1 负责调节细胞增殖和迁移，并且还被发现在不同癌症（包括胰腺癌和乳腺癌）中发挥关键作用。 许多癌症驱动突变会诱导 PDK-1 靶标的激活，包括 Akt、S6K（p70 核糖体 S6 激酶）和 SGK。 因此，PDK1 是多种促存活和致癌蛋白激酶的关键激活剂，因此它作为肿瘤药物靶点引起了人们的极大兴趣。

丙酮酸脱氢酶 (PDH) 是一种线粒体多酶复合物，可催化丙酮酸的氧化脱羧作用，是负责调节哺乳动物碳水化合物燃料稳态的主要酶之一。 酶活性受磷酸化/去磷酸化循环的调节。 特定丙酮酸脱氢酶激酶 (PDK) 对 PDH 的磷酸化导致失活。 已发现该基因的多个选择性剪接转录物变体。 [RefSeq 提供，2013 年 6 月]

Mar 1, 2022 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML)....

Nov 6, 2017 · Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH +...