Transcriptional repression of IRF7 by MYC is critical for type I ...
IRF7 is a critical regulator of type I IFN production when pathogens are detected by Toll-like receptor (TLR) 7/9 in pDC. However, hyperactivation of pDC can cause life-threatening …
IRF5, IRF8, and IRF7 in human pDCs - Wiley Online Library
2013年7月4日 · Following phosphorylation, IRF7 translocates to the nucleus and initiates the transcription of type I and type III IFNs. IRF5 positively regulates the induction of pro …
IRF7: activation, regulation, modification and function
2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial...
Activation of interferon regulatory factor 7 in plasmacytoid …
Pancreatic IRF7 expression was examined in surgically operated specimens from type 1 AIP patients. Results: IRF7 activation was induced in pancreatic pDCs in experimental AIP. siRNA …
An efficient method for gene silencing in human primary …
2016年7月14日 · We successfully silenced Toll-Like Receptor 7 (TLR7), CXCR4 and IFN regulatory factor 7 (IRF-7) gene expression in pDC as assessed by RT-qPCR or cytometry. …
IRF7: role and regulation in immunity and autoimmunity
2023年8月9日 · IRF7 is a lymphoid-specific factor that is predominantly expressed in the cytoplasm of the spleen, thymus, and peripheral blood lymphocytes, such as B cells, …
NFATC3 promotes IRF7 transcriptional activity in plasmacytoid ...
2016年10月10日 · By using a direct biochemical approach in a pDC cell line (Gen2.2 cells), we have identified that transcriptional factor NFATC3 specifically binds to and positively regulates …
Regulation of IRF7 Through Cell Type-Specific Protein Stability
2006年3月3日 · However, plasmacytoid dendritic cells (pDC), which constitute the major circulating IFN producing cell type, displayed a distinct pattern of regulation. Infection of …
Opn: key regulator of pDC interferon production - Nature
2006年5月1日 · Plasmacytoid dendritic cells selectively express Toll-like receptors 7 and 9 and respond to virus infection by triggering massive interferon production, a pathway regulated by …
IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the ...
Using RNA interference studies, the authors identify critical roles for IRF5 and IRF8 as positive and negative regulators, respectively. In contrast, knockdown of IRF7 had no significant effect …