PD-L1作为最重要的免疫检查点之一，除了可组成型低表达于APCs和多种非造血细胞，也可被炎性细胞因子包括干扰素 (IFN)、肿瘤坏死因子仅 (TNF-α)和血管内皮生长因子 (VEGF)等诱导表达 …

A PD-L1 test uses a sample of cancerous tumor tissue to measure how much of a protein called PD-L1 is found on the cancer cells. If you have certain types of cancer, PD-L1 testing can …

2024年5月18日 · Research indicates that the PD-1/PD-L1 pathway plays a crucial role in regulating autoimmunity responses and peripheral tolerance. Notably, anti-PD-1/PD-L1 …

Your tumor tested positive for the PD-L1 biomarker. It is important to understand what this means and how it may affect lung cancer treatment. WHAT IS PD-L1? PD-L1 (programmed cell death …

PD-L1 expression by tumor cells and TILs assessed by immunohistochemistry (IHC) is considered the most reliable predictive marker for response to immunotherapy in different …

Tumour cells may express PD-L1, with subsequent PD-1 binding and inhibition of T-cell activation allowing cancer cells to evade immune attack. PD-L1 expression can be driven by both …

2021年2月12日 · PD-L1, quantified using immunohistochemistry assays, is currently the most widely validated, used and accepted biomarker to guide the selection of patients to receive …

2025年1月2日 · Our findings identified plasticity as a relevant hallmark of ICI-mediated HPD by demonstrating that ICIs can modulate the IFN-γ and PD-L1 pathways, driving tumor cell …

2017年5月22日 · What is PD-L1? PD-L1 is a protein that allows some cells to escape an attack by the immune system. Extending from the cancer cell surface, PD-L1 interacts with a protein …

2024年12月4日 · PD-L1 overexpression in APCs inhibited the immune responses of autoreactive T cells in EAE, whereas PD-L1-deficient EAE mice had increased levels of IFN-γ, TNF-α, and …