2025年3月30日 · PCK1 (Phosphoenolpyruvate Carboxykinase 1) is a Protein Coding gene. Diseases associated with PCK1 include Phosphoenolpyruvate Carboxykinase Deficiency, Cytosolic and Phosphoenolpyruvate Carboxykinase Deficiency. Among its related pathways are Gene expression (Transcription) and Gluconeogenesis.

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene. [5][6] This enzyme is a main control point for the regulation of gluconeogenesis.

该基因是调节糖异生的主要控制点。 由该基因编码的胞质酶与 GTP 一起催化草酰乙酸形成磷酸烯醇丙酮酸，同时释放二氧化碳和 GDP。 该基因的表达可以通过胰岛素、糖皮质激素、胰高血糖素、cAMP 和饮食进行调节。 该基因的缺陷是细胞溶质磷酸烯醇丙酮酸羧激酶缺乏症的原因。 所编码蛋白质的线粒体同功酶也已被表征。 [RefSeq 提供，2008 年 7 月] This gene is a main control point for the regulation of gluconeogenesis.

2020年4月8日 · PCK1 is the rate-limiting enzyme of gluconeogenesis in the liver and kidney, and converts oxaloacetate and GTP into phosphoenolpyruvate and CO 2 8. In humans, cytosolic PCK1 shares 63.4%...

2023年3月14日 · Phosphoenolpyruvate carboxykinase 1 (PCK1) is the first rate-limiting enzyme in gluconeogenesis and converts oxaloacetate to phosphoenolpyruvate in the...

Phosphoenolpyruvate carboxykinase 1 (PCK1 or PEPCK-C) is a cytosolic enzyme converting oxaloacetate to phosphoenolpyruvate, with a potential role in gluconeogenesis, ammoniagenesis, and cataplerosis in the liver. Kidney proximal tubule cells display high expression of this enzyme, whose importance is currently not well defined.

Phosphoenolpyruvate carboxykinase 1 (PCK1) is the first rate-limiting enzyme in the gluconeogenic pathway and catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) [19]. There is growing evidence that PCK1 mediates cancer development through metabolic and nonmetabolic processes in specific cases [19 – 22].

胞质异构体pck1(也称为pepck-c或pepck1)是肝脏糖异生的初始酶，催化草酰乙酸(oaa)转化为 磷酸烯醇丙酮酸 (pep)。既往研究发现，pck1在肝细胞癌(hcc)中下调，敲除pck1可增强肝癌在体内和体外的增殖和转移。

PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer. Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation.

2019年11月13日 · 磷酸烯醇式丙酮酸羧激酶基因 (phosphoenolpyruvate carboxykinase,PEPCK)编码的胞质磷酸烯醇式丙酮酸羧激酶1 (phosphoenolpyruvate carboxykinase 1,PCK1)是调节糖异生过程中的限速酶,参与维持血糖水平.它广泛参与糖代谢、脂代谢、衰老、糖尿病以及肿瘤细胞增殖和凋亡等代谢和生物学进程.本文对PCK1在以上物质代谢和生物学进程中的研究进展作一综述,为进一步探究PCK1参与糖尿病、肿瘤及衰老等疾病的分子机制提供理论基础,也为PCK1作为新的 …