PC-3 is a cell line initiated from a bone metastasis of a grade IV prostatic adenocarcinoma from a 62-year-old, White, male.

Prostatic small cell neuroendocrine carcinoma (SCNC) is a variant form of prostate cancer (PC). In contrast to adenocarcinoma, the tumor cells of SCNC do not form glands and are negative …

LNCaP and PC3 have been the most commonly used PC cell lines but they possess significantly different characteristics, the most important being that LNCaP cells express luminal differentiation markers AR and PSA while PC3 cells do not.

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Wild-type p53 suppresses growth of human prostate cancer cells containing …

Presently, using the PC3 prostate cancer cell model, we confirm the occurrence of a minor (~10%) subpopulation of PC3 cells with a stable holoclone morphology, and demonstrate that these holoclones form spheres with high efficiency, and conversely, PC3-derived spheres yield holoclones with high efficiency, supporting the CSC nature of the PC3 ...

2020年9月2日 · LNCaP, PC3, and 22Rv1 were commonly used cell lines in the research of prostate cancer. The biological characteristics of these three common prostate cancer cell lines are introduced herein.

2018年12月1日 · PC3 cell line demonstrates two types of grow, adherent and in suspension. Cells from each type of growing pattern present different ultrastructure. Zona pellucida proteins expression was found on both prostate cancer and PC3 cells. Pavement-cells (adherent) have a higher expression of ZP1, ZP3 and ZP4 mRNA.

The bone metastasis-derived PC3 and the lymph node metastasis-derived LNCaP prostate cancer cell lines are widely studied, having been described in thousands of publications over the last four decades. Here, we report short-read whole-genome ...

PC3-cells were divided into pavement and aggregated cells. We observed new ultrastructural features in pavement and aggregated cells, with the later exhibiting two different cell types.

2012年8月14日 · Pleiotrophin seems to have a significant role in prostate cancer cell growth and to mediate the stimulatory actions of other factors that affect prostate cancer cell functions. However, all studies carried out up to date are in vitro, using different types of human prostate cancer cell lines.