PARP family members can be found spread across all domains and continue to be essential molecules from lower to higher eukaryotes. Poly (ADP-ribose) polymerase 1 (PARP-1), newly termed ADP-ribosyltransferase D-type 1 (ARTD1), is a ubiquitously expressed ADP-ribosyltransferase (ART) enzyme involved i …

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.

Poly (ADP‐ribose) polymerase (PARP) enzymes are a family of proteins involved in a number of cellular processes including gene regulation, chromatin remodelling, DNA repair and apoptosis. 1 These enzymes are present in all eukaryotes except yeast. 2 PARPs can either transfer a single unit of (ADP‐ribose) or more than one (ADP‐ribose ...

2013年8月6日 · We show that most PARPs are cytoplasmic, identify cell cycle differences in the ratio of nuclear to cytoplasmic poly (ADP-ribose) and identify four phenotypic classes of PARP function. These...

Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP-ribose to target proteins. PARPs play an important role in various cellular processes, including modulation of chromatin structure, transcription, replication, recombination, and DNA repair.

The PARP family has a variety of regulatory domains and structural features that matches the diverse aspects of cellular biology that PARP enzymes regulate. As highlighted here, PARP-1 and Tankyrase offer a glimpse of the interesting mechanisms that regulate PARP enzymes.

Poly (ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks.

2025年3月8日 · Poly (ADP-ribose) polymerases (PARPs) are a family of proteins that catalyze the transfer of ADP-ribose units from NAD+ to target proteins (ADP-ribosylation), thus playing pivotal roles in...

2017年7月5日 · Poly (ADP-ribose) polymerase 1 (PARP1) was the first member of the PARP family to be identified. The PARP family now comprises 18 members. PARP1 post-translationally modifies itself and a range...

Here we primarily review recent structural insights into the regulation and catalysis of two family members: PARP-1 and Tankyrase. PARP-1 has multiple roles in the cellular response to DNA damage and the regulation of gene transcription, and Tankyrase regulates a diverse set of target proteins involved in cellular processes such as mitosis ...