PARP1 - Wikipedia
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD + ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. [5] …
The DNA-Binding Domain of Human PARP-1 Interacts with
2011年3月18日 · Here, we report a biophysical and structural characterization of the F1 and F2 fingers of human PARP-1, both as independent fragments and in the context of the 24-kDa …
Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and …
2019年2月25日 · Understanding the details of PARP1 catalytic mechanism and its regulation is especially important in light of PARP-targeted therapy and may significantly aid to PARP …
Structural dynamics of DNA strand break sensing by PARP-1 at a …
2022年11月2日 · Sm FRET studies of PARP-1 recognition of DNA lesion show that binding of F1F2 fragment results in a kinked DNA, while binding of F2 fragment alone yields an …
邵正萍团队Trends in Genetics综述丨PARP1失活的复杂世界
2024年11月17日 · 聚ADP-核糖（PAR）聚合酶-1（PARP-1）是PARP家族蛋白中最重要的成员，负责超过80%的细胞内的多聚ADP核糖基化 (PARylation)活动，在一系列细胞生命过程，特 …
PARP1: Structural insights and pharmacological targets for
Poly (ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, including the base …
PARP1: Structural insights and pharmacological targets for …
2021年7月1日 · Poly (ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair pathways, …
PARP-1 Activation Requires Local Unfolding of an
2015年12月3日 · Poly (ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR from substrate NAD + to regulate multiple cellular processes. DNA breaks …
The DNA-binding domain of human PARP-1 interacts with DNA ... - PubMed
2011年3月18日 · Here, we report a biophysical and structural characterization of the F1 and F2 fingers of human PARP-1, both as independent fragments and in the context of the 24-kDa …
Dynamics of the HD regulatory subdomain of PARP-1; substrate ... - PubMed
2021年2月26日 · PARP-1 is a key early responder to DNA damage in eukaryotic cells. An allosteric mechanism links initial sensing of DNA single-strand breaks by PARP-1's F1 and F2 …
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