Herein an activatable nanoprobe (MoS2@PDA–PEG/peptide, MPPF) with dual-mode near-infrared fluorescence (NIRF)/ratiometric photoacoustic (PA) imaging of endogenous furin activity has been developed. The MPPF nanoprobes were constructed by the covalent functional

MPPF, with the full name 2'-methoxyphenyl-(N-2'-pyridinyl)-p-fluoro-benzamidoethyipiperazine, is a compound that binds to the serotonin-1A receptor. Labeled with fluorine-18 it has been used as a radioligand with positron emission tomography. [1]

MPPF（2'-[18F]Fluoro-3'-(2-methoxyphenyl)propylidene]thiosemicarbazone）是一种放射性荧光成像剂，常用于肿瘤的诊断和研究。 MPPF的性质： - MPPF是一种放射性化合物，其分子结构中含有18F放射性同位素。

[18F]MPPF: 一种5-HT1A receptor拮抗剂、PET imaging药物，由Institute for Neurodegenerative Disorders (Institute for Neurodegenerative Disorders)公司最早进行研发，目前全球最高研发状态为临床前，作用机制: 5-HT1A receptor拮抗剂(5-羟色胺1A受体拮抗剂),PET imaging(正电子发射断层成像术增强剂 ...

2000年7月1日 · This paper summarizes the present status of the researches conducted with [18 F]4-(2′-methoxyphenyl)-1-[2′-[N-(2′′-pyridinyl)-p-fluorobenzamido]ethyl]-piperazine known as [18 F]p-MPPF, a new 5-HT 1A antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry ...

2011年9月27日 · 本研究的基本目标是评估 [18F]MPPF PET 成像作为评估帕金森病 (PD) 研究参与者大脑中血清素 5HT1a 受体活性的工具。 将招募大约 40 名患有帕金森病的受试者和 20 名健康对照受试者参与本研究的 2 个项目。 所有受试者都将接受书面知情同意书和筛选评估，包括基线临床实验室测试、基线身体和神经学评估以及基线认知评估。 项目 1 中的受试者（20 名 PD 和 20 名 HC 受试者）将被要求接受单次推注 [18F]MPPF，然后进行连续正电子发射断层扫描 (PET) 成 …

2006年7月1日 · With this goal, the desmethylated 4- (2′-methoxyphenyl)-1- [2′- [N - (2″-pyridinyl)- p -fluorobenzamido]ethyl]-piperazine (p -MPPF), identified as p -DMPPF, was synthesized, labeled with fluorine-18 and evaluated through ex vivo tissue distribution in rats.

Recently, the selective 5-HT(1A) receptor antagonist, MPPF, has been successfully labeled with [(18)F]fluorine ([(18)F]MPPF), and an increasing number of academic and industry centres have used this radiotracer in preclinical and clinical studies.

2021年12月5日 · 4-(2´-Methoxyphenyl)-1-[2´-(N-2´´-pyridinyl)-p-[18 F]fluorobenzamido]ethylpiperazine (p-[18 F]MPPF) is a radioligand developed for positron emission tomography (PET) imaging of serotonin-1A (5 …

No-carrier-added 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1 piperazinyl]ethyl-N-2-pyridinyl-benzamide (p-[18F]MPPF) was synthesized by nucleophilic substitution of the corresponding nitro compound in the presence of Kryptofix 222 and K2CO3 by microwave heating (3 min, 500 W) using a remotely controll …