Th2 differentiation, which is critical for allergic airway disease, is triggered by signals of the T-cell receptor (TCR) and the cytokines generated during polarization, particularly IL-4. We determine here the potential role of the signaling adapter p62 in T-cell polarization.

p62作为一种细胞自噬相关蛋白，参与了肿瘤细胞的增殖、凋亡、侵袭和转移等关键生物学事件。本综 述从p62的功能及调控机制、p62在结直肠癌的发生发展相关性研究、p62作为治疗靶点的应用前景系统

p62调控nf-κb主要有两种方式，其一是通过pb1结构域结合apkc、zz结构域结合rip，激活tnf-α信号介导的 nf-κb 通路；其二是通过 tb 结构域结合traf，形成p62-traf6-ikkβapkc的信号复合物激活nfκb 通路。

摘要：螯合体1 (SQSTM1/p62)是一种选择性自噬接头蛋白，在清除待降解蛋白、维持细胞内蛋白质稳态中发挥重要的调控作用。 p62蛋白具有多个功能结构域，介导与多种蛋白质发生相互作用进而精确调节特定的信号通路，从而将p62蛋白与氧化防御系统、炎症反应和营养感知等重要生命过程联系起来。 研究表明p62的突变或者表达异常与多种疾病的发生发展过程密切相关，包括神经退行性疾病、肿瘤、感染性疾病、遗传性疾病以及慢性疾病等。 本文综述了p62蛋白的结构特征 …

摘 要：p62是一种多功能泛素结合蛋白，参与泛素蛋白酶体系统(ubiquitin-proteasome system, UPS)和自噬-溶酶体系统两种 蛋白降解过程。 p62作为一种信号转导途径中的支架和适配子蛋白，其分子结构中的多个功能结构域可与其它蛋白质相互作

SQSTM1/p62 是由SQSTM1基因编码的一种多功能泛素化结合的接头蛋白,参与泛素蛋白酶体系统和自噬-溶酶体系统两种蛋白质降解过程,同时具有质核穿梭功能,在DNA损伤修复和氧化应激反应中发挥重要作用。 p62作为细胞接头蛋白,是细胞内多种蛋白复合物的主要成分[1],其分子结构. 细胞的生长、自噬、癌变等生理病理过程。 p62不仅是自噬体与底物之间的适配蛋白,反过来也调节着自噬的过程。 当自噬活性减弱时,p62蛋白会在细胞质中累积,是反映自噬活性的标记蛋白之一[5]。 …

p62 is an autophagy substrate that is used as a reporter of autophagy activity. Recently, p62 was also shown to deliver ubiquitinated proteins, such as tau, to the proteasome for degradation. In addition, it can shuttle between the nucleus and cytoplasm to bind with ubiquitinated cargoes and facilitate nuclear and cytosolic protein quality control.

2006年8月9日 · We determine here the potential role of the signaling adapter p62 in T-cell polarization. We report using p62-/- mice and cells that p62 acts downstream TCR activation, and is important for Th2 polarization and asthma, playing a significant role in the control of the sustained activation of NF-kappaB and late synthesis of GATA3 and IL-4 by ...

2016年10月20日 · However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.

2016年6月13日 · p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was not explored.